Simultaneous sustained delivery of NSAID bromfenac and lubricant polyvinylpyrrolidone by vitamin E nanobarrier contact lenses [0.03%]
一种维生素E纳米屏障接触镜同时持续递送非甾体抗炎药溴芬酸和增润剂聚乙烯吡咯酮的方法
Bommanahalli Nagaraju Kumara,Anuj Chauhan
Bommanahalli Nagaraju Kumara
Purpose: Cataract surgery is commonly followed by daily administration of multiple eye-drops of antibiotics and anti-inflammatory drugs such as moxifloxacin, dexamethasone and bromfenac. Drop-less cataract surgery elimina...
Protein-based nanocarrier delivering kartogenin derivative to cartilage matrix for intra-articular treatment of osteoarthritis [0.03%]
一种蛋白质基纳释体系用于关节腔给药治疗骨关节炎
Luca Morici,Sébastien Jenni,Bill Hakim et al.
Luca Morici et al.
Osteoarthritis is the most common degenerative joint disease worldwide, yet no intra-articular disease-modifying osteoarthritis drugs (DMOADs) have succeeded in clinical trials due to poor therapeutic outcomes and limited cartilage targetin...
Federico Machinandiarena,Domenico D&#x;Atri,Lisa M Jenkins et al.
Federico Machinandiarena et al.
RNA therapy, which includes delivery of mRNA or siRNA, shows promise for treating various diseases, but difficulties in targeting specific cell types and low efficiency of loading RNA into nanoparticles remain hurdles to achieving widesprea...
An injectable in situ hydrogel platform for sustained drug release against Glioblastoma [0.03%]
一种针对胶质母细胞瘤的长效药物释放的可注射原位水凝胶平台
Weizhou Yue,Tianqi Wang,Lingxiao Xie et al.
Weizhou Yue et al.
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite aggressive surgical and medical treatments, the prognosis for patients with GBM remains grim and tumor recurrence is inevitable. Long-acting localize...
Panobinostat-Loaded Albumin Nanoparticles for the Treatment of Pancreatic Cancer [0.03%]
用于胰腺癌治疗的载蛋白酶抑制剂泛昔洛韦白蛋白纳米粒
Paras Mani Giri,Arpita Ghosal,Travis Kruse et al.
Paras Mani Giri et al.
Panobinostat is a highly active and potent non-selective histone deacetylase inhibitor (HDACi) that demonstrates significant anticancer activity against various cancers, including pancreatic cancer. However, like other HDAC inhibitors, its ...
Mechano-chemical encapsulation of gemcitabine hydrochloride on metal-organic framework, preparation of shaped pellets, delayed drug release, and time-dependent toxicity to PANC-1 cancer cells [0.03%]
基于金属有机骨架的吉西他滨盐酸盐固载控释及对PANC-1癌细胞的时间依赖性毒性研究
Sheriff Umar,Jonathan Catazaro,James Wachira et al.
Sheriff Umar et al.
Gemcitabine is a powerful anticancer antimetabolite drug which is usually administered as hydrochloride salt (GemHCl), but its systemic administration is accompanied by the undesirable "burst" phenomenon and its adverse side effects. To avo...
Impact of PEGylated liposomes on cytotoxicity of tamoxifen and piperine on MCF-7 human breast carcinoma cells [0.03%]
聚乙二醇脂质体对tamoxifen和辣椒素对MCF-7人乳腺癌细胞的细胞毒性的影响
Klaudi K Vaiphei,A Prabakaran,Singh Snigdha et al.
Klaudi K Vaiphei et al.
Tamoxifen (TMF) is an anticancer agent used for managing estrogen receptor-positive breast cancer. It has limited therapeutic efficacy against breast cancer, which could be enhanced by the coadministration of herbal drugs like piperine (PIP...
Enhanced Macrophage Uptake of Spray-Dried Phosphatidylserine-Loaded Microparticles for Pulmonary Drug Delivery Applications [0.03%]
用于肺部药物输送的喷雾干燥载有磷脂酰丝氨酸微粒的巨噬细胞摄取增强作用
Matthew T Freeman,Arianne Parvaresh-Rizi,Samantha A Meenach
Matthew T Freeman
Macrophages are an integral part of the innate immune system and act as a first line of defense to pathogens; however, macrophages can be reservoirs for pathogens to hide and replicate. Tuberculosis, influenza virus, and severe acute respir...
Electrospun nanofibers: Focus on local therapeutic delivery targeting infectious disease [0.03%]
静电纺纳米纤维：针对传染病的局部治疗递送方法研究重点
Anthony J Kyser,Bassam Fotouh,Victoria Harris et al.
Anthony J Kyser et al.
Whether it be due to genetic variances, lack of patient adherence, or sub-optimal drug metabolism, the risk of antibiotic resistance from medications administered systemically continues to pose significant challenges to fighting infectious ...
New Cellular Models to Support Preclinical Studies on ICAM-1-Targeted Drug Delivery [0.03%]
用于ICAM-1靶向药物递送的临床前研究的新细胞模型
Marco Vigo,Elena Haro-Martínez,Eloy Ruiz et al.
Marco Vigo et al.
Intercellular adhesion molecule 1 (ICAM-1) is a cell-surface protein actively explored for targeted drug delivery. Anti-ICAM-1 nanocarriers (NCs) target ICAM-1-positive sites after intravenous injection in animal models, but quantitative me...