AP-1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids [0.03%]
AP-1B调控小鼠肠类器官增殖和分化的多个阶段
Maela Duclos,Anne Bourdais,Ophélie Nicolle et al.
Maela Duclos et al.
Gut homeostasis relies on the tightly controlled balance between intestinal stem cell self-renewal and differentiation. The clathrin adaptor complex AP-1B plays a pivotal role in establishing the polarity of enterocytes as well as in the as...
Oxidative Stress and Nrf2 Signaling Role in Oral Squamous Cell Carcinoma: A Double-Edged Sword [0.03%]
氧化应激和Nrf2信号在口腔鳞状细胞癌中的双刃剑作用
Ashraf Ullah Khan,Adnan Khan,Bushra Shal et al.
Ashraf Ullah Khan et al.
Background: Oxidative stress has a significant role in the origination and progression of oral squamous cell carcinoma (OSCC) by interrupting cellular redox homeostasis and gene regulation. The nuclear factor erythroid 2-...
Wnt Stimulation and Inhibition in the Development and Phenotype of Patient-Derived Gallbladder Organoids [0.03%]
患者衍生胆囊类器官的Wnt刺激和抑制在发育和表型中的作用
Ankita Dutta,Payel Guha,Akshaya Vijayan Selvarajan et al.
Ankita Dutta et al.
Background: Gallbladder cancer (GBC) is a highly lethal malignancy with limited experimental models to study disease biology or evaluate therapeutic responses. Although canonical Wnt activation is commonly used for patien...
From Genomic Alterations to Functional Tumor Biology: Integrating Organoids and Organ-on-a-Chip in Colorectal Cancer [0.03%]
从基因组改变到功能肿瘤生物学：在结直肠癌中整合类器官和芯片上的器官
Woei-Yau Kao,Lu-Kai Wang,Fu-Ming Tsai
Woei-Yau Kao
Colorectal cancer (CRC) develops through the stepwise accumulation of genetic alterations, including mutations in APC, KRAS, and TP53, which drive tumor initiation and progression. Although advances in genomic profiling have significantly i...
Delta-Cell Area is Unchanged in Human Pregnancy: Evidence From Immunohistochemistry [0.03%]
人妊娠期间δ-细胞区不变的证据来自免疫组化分析
Faheem Seedat,Neva Kandzija,Edward Drydale et al.
Faheem Seedat et al.
Aim: Pancreatic islet δ-cells produce somatostatin, a paracrine regulator of insulin and glucagon secretion within islets. Although adaptive changes in α- and β-cell populations during pregnancy have been described in ...
Rearrangement of the Cell Chaperone Machinery in Human Fibrosarcoma HT1080 Cells With the Knocked-Out HSP90AA1 Gene Encoding Hsp90α [0.03%]
人成纤维肉瘤HT1080细胞中HSP90AA1基因敲除编码Hsp90α的细胞伴侣 machinery 重排
Viktoria Petrenko,Veronika Vrublevskaya,Yuri Skarga et al.
Viktoria Petrenko et al.
Background: Two isoforms of the 90-kDa heat shock protein (Hsp90), stress-inducible Hsp90α and constitutively expressed Hsp90β, function in mammalian cells as molecular chaperones that promote the folding of specific cl...
STAT Signaling and Its Anti-Apoptotic Effects in Dehydrated Xenopus laevis [0.03%]
_STAT信号及其在干旱处理下非洲爪蟾的抗凋亡效应
Yulia Biggar,Akshay A Kamath,Sarah A Breedon et al.
Yulia Biggar et al.
Xenopus laevis survives seasonal droughts by entering a hypometabolic state known as aestivation. One of the mechanisms employed by X. laevis to mitigate aestivation-induced tissue atrophy is gene regulation of pro-survival proteins. We fur...
Integrated 2D-3D Proteomic Profiling Identifies MLK4 as a Microenvironment-Responsive Regulator of Chemotherapeutic Resistance in Human Glioblastoma Cells [0.03%]
整合的二维和三维蛋白质组分析鉴定出MLK4是人类胶质母细胞瘤细胞中微环境响应型化疗耐药调节因子
Wannawat Khotchawan,Pakorn Ruengket,Pakpoom Kheolamai et al.
Wannawat Khotchawan et al.
Background: Therapeutic resistance is a major cause of treatment failure in glioblastoma (GBM), highlighting the need for physiologically relevant models to identify actionable resistance mechanisms. While two-dimensional...
Mitochondrial Activity Localization in the Skeletal Muscle and Its Individual Fibers Across Tetrapods [0.03%]
四足动物骨骼肌及其单个肌纤维的线粒体活性定位
Unmod Senapati,Subhasmita Rout,Sunil Pani et al.
Unmod Senapati et al.
Mitochondria exhibit a complex spatially organized distribution within muscle, tailored to the energy requirements of ATPases and contractile filaments, which exhibit precise intracellular positioning. Mitochondrial distribution varies acro...