A novel platform using a regenerable SDS-functionalized membrane with AF4-DAD-MALS for online-operated enrichment and detection of polydisperse nanoplastics in biological samples [0.03%]
一种新型平台，采用可再生的SDS功能化膜与AF4-DAD-MALS联用，在线富集和检测生物样品中多分散性纳米塑料
Xingling Luo,Aobo Geng,Yingting Wu et al.
Xingling Luo et al.
In view of the importance and urgency of elucidating the internal exposure toxicity and transport mechanisms of nanoplastics (NPl) in organisms for assessing their health risks, we developed a novel analytical method that integrates online ...
Analysis of dithiocarbamates in berries and leafy vegetables by ultra-high performance liquid chromatography coupled with tandem mass spectrometry [0.03%]
超高效液相色谱-串联质谱法测定浆果和绿叶蔬菜中的二硫代氨基甲酸盐残留量
Cécile Dionne Edoa,Justine Fontaine,Ken Goeury et al.
Cécile Dionne Edoa et al.
A sensitive method has been developed for the analysis of the three subclasses of dithiocarbamates (DTCs): (dimethyl dithiocarbamates (DMDs), ethylenebisdithiocarbamates (EBDs), propylenebisdithiocarbamates (PBD)) in berries and leafy veget...
A ratiometric FRET sensor using Ti3C2Tx MXene for intracellular microRNA-21 quantitative measurement [0.03%]
一种基于Ti3C2Tx MXene的比率型FRET传感器用于细胞内microRNA-21的定量测量
Yu Zhao,Yuteng Fan,Yuxin Luo et al.
Yu Zhao et al.
A ratiometric fluorescence resonance energy transfer (R-FRET) sensor based on two-dimensional Ti3C2Tx MXene nanosheets has been developed for intracellular miRNA-21 detection. The sensor comprises MXene nanosheets and two hairpin probes lab...
A hypoxia activated fluorescent probe for the specific visualization of mitochondrial dysfunction in tumors [0.03%]
一种用于特异性可视化肿瘤中线粒体功能障碍的低氧激活型荧光探针
Qilong Zhang,Chun Dai,Huina Wang et al.
Qilong Zhang et al.
Selectively monitoring the mitochondrial dysfunction and viability of tumors is an important task for the treatment of cancer and is helpful for determining the appropriate radiotherapy and chemotherapy dose to minimize side effects. Howeve...
Fingerprinting combined with chemometrics: new strategies and advances in quality evaluation of traditional Chinese medicine [0.03%]
指纹图谱结合化学计量学在中药质量评价中的新策略和进展
Yibing Yao,Mingze Li,Lijun Zhang et al.
Yibing Yao et al.
In the field of global health, the quality of Traditional Chinese Medicine (TCM) holds pivotal significance. Ensuring the clinical efficacy and medication safety of TCM not only enhances international trust in TCM, injecting strong impetus ...
Establishment and evaluation of the detection method for human adenovirus and its subtypes based on RAA-LFD technology [0.03%]
基于RAA-LFD技术的人类腺病毒及其分型的检测方法的确立及评价
Mengru Liu,Guiqi Hu,Yu Yu et al.
Mengru Liu et al.
In this research, we developed a rapid assay for detecting human adenovirus (HAdV) and its prevalent subtypes (including HAdV3, HAdV4, HAdV7, HAdV14, HAdV11, and HAdV55) based on recombinase-mediated isothermal amplification combined with l...
A benzothiazole-based fluorescent probe for hypochlorite - highly sensitive detection and live-cell imaging research [0.03%]
一种用于检测次氯酸的苯并噻唑类荧光探针研究——高灵敏度及活细胞成像性能
Kelong Fang,Xiaozhen Ma,Yuliang Jiang
Kelong Fang
Hypochlorous acid (HOCl), a key reactive oxygen species, is generated in vivo through the catalytic action of myeloperoxidase and plays a crucial role in innate immunity. However, dysregulation of HOCl levels can contribute to the developme...
A Bst-driven Cas12a cascade amplification strategy for microRNA detection [0.03%]
基于BST酶的Cas12a级联扩增微流控芯片用于microRNA检测新技术
Quanzhong Xu,Mingfang Ji
Quanzhong Xu
Quantification of trace microRNAs is crucial for early disease diagnosis but remains technically challenging. Herein, we developed an ultrasensitive fluorescence platform for microRNA-21 (miR-21) detection by integrating Bst DNA polymerase ...
Ambient ionization mass spectrometry for rapid screening of illegal adulteration in traditional Chinese medicines: a review [0.03%]
传统中药中非法添加物的快速筛查技术——大气压离子化质谱法研究进展综述
Fangliang Yang,Wei Shen,Jingjing Ying
Fangliang Yang
Illegal adulteration of traditional Chinese medicines has become a critical global safety concern, driven by the covert addition of synthetic pharmaceuticals such as phosphodiesterase type five inhibitors, anorectic agents, nonsteroidal ant...
A novel APE1-assisted cycling amplification for rapid and ultrasensitive SERS detection of TK1 mRNA in human serum [0.03%]
一种新型APE1辅助循环扩增技术用于人血清中TK1 mRNA的快速超灵敏SERS检测
Changqing Du,Anran Li,Jinye Qiu et al.
Changqing Du et al.
Quantitative mRNA expression levels are essential for differential and clinical diagnoses. In this work, we present an apurinic/apyrimidinic endonuclease 1 (APE1)-assisted SERS sensing platform for rapid and ultrasensitive detection of TK1 ...