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Simultaneous measurement of piperacillin, tazobactam and meropenem in patient samples using LC-MS/MS to support β-lactam therapeutic drug monitoring

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Background: accurate therapeutic drug monitoring (TDM) of β-lactam antibiotics such as meropenem and piperacillin-tazobactam is essential in critically ill patients, where profound pharmacokinetic variability may lead to subtherapeutic exposure or toxicity. P... ...