Multidimensional information detection of liver cancer cell exosomes treated with shikonin [0.03%]
漆致肝癌细胞外泌体的多维度信息检测分析
Jian Qiao,Jingran Zhang,Chunli Qin et al.
Jian Qiao et al.
Exosomes were recently recognized as mediators of intercellular communication and as potential biomarkers associated with cancer. However, the multidimensional characterization of exosomes secreted by cancer cells after drug treatment remai...
A green analytical method for identification and quantification of carcinogenic impurity N-nitroso-desformyl riociguat in riociguat formulations by UHPLC-MS/MS [0.03%]
用于识别和量化伐尼克兰杂质N-亚硝基脱氧伐尼克兰的绿色分析方法，并通过UHPLC-MS/MS进行定量分析研究
Veeraswami Boddu,Manoj Kumar Mandapaka
Veeraswami Boddu
Riociguat, a vasodilatory drug for treating pulmonary hypertension (PH), might generate a nitrosamine drug substance-related impurity (NDSRI), reported as N-nitroso-desformyl riociguat (NNDFR). NDSRIs are a class of nitrosamine impurities t...
A MIL-53-PVDF mixed-matrix membrane for dispersive membrane solid-phase extraction of phenoxycarboxylic acid herbicides from environmental water samples followed by HPLC determination [0.03%]
基于微孔聚合物膜的分散固相萃取纤维的制备及其在水样中草甘膦等除草剂检测中的应用研究
Ronghui Xiao,Mingshan Jiang,Jiping Ma
Ronghui Xiao
A MIL-53-PVDF mixed-matrix membrane was prepared for the enrichment of four phenoxycarboxylic acid herbicides (2,4-D, MCPA, 2,4-DP, and 2,4-DB) in environmental water samples, and the enriched analytes were determined by high performance li...
UV-Vis determination of acetate in ethanol electrolysis for renewable hydrogen production [0.03%]
乙醇电解制氢过程中乙酸积累的紫外吸收测定法
Zuyao Li,Jing Li,Chaoyang Jiang et al.
Zuyao Li et al.
Electrochemical oxidation of ethanol can simultaneously produce hydrogen and value-added acetate, but accurate quantification of acetate in ethanol-rich, high-ionic-strength alkaline electrolytes remains challenging. Here, we report a cost-...
Analytical characterization of bulk R-Salt and its odor profile to establish a framework for canine detection [0.03%]
批量R-盐的分析表征及其气味谱图的建立以构建犬检测框架
Janet Crespo-Cajigas,Melissa J Clinard,Shawanda Roberts et al.
Janet Crespo-Cajigas et al.
In early 2025, an improvised explosive known as R-Salt (hexahydro-1,3,5-trinitroso-1,3,5-triazine), was recovered from multiple improvised explosive devices in a terrorist attack in New Orleans, USA. R-Salt is not commonly included in canin...
Enzyme-free and product-accelerated DNA walker cascade for ultrasensitive detection of tic disorder-associated microRNA [0.03%]
一种无酶高效环化反应体系用于微小核糖核酸的超灵敏检测
Wei Li,Xiaobin Dou
Wei Li
Tic disorders (TDs) are prevalent neuropsychiatric conditions in children, yet early diagnosis remains challenging due to limited availability and high sequence homology of associated microRNA biomarkers. Existing detection methods often su...
Breaking the bottlenecks in nanozyme-antibody conjugate preparation: challenges, optimization strategies, and applications of in vitro diagnostics [0.03%]
纳米酶抗体偶联物制备瓶颈突破：体外诊断应用面临的挑战、优化策略及应用展望
Kehui Yu,Mengjun Wang,Haoan Wu et al.
Kehui Yu et al.
Enzyme-labeled antibodies serve as the fundamental pillars of immunoassay-based biosensing, providing the necessary molecular recognition and signal amplification for the detection of trace analytes in complex matrices. As robust mimics of ...
One-pot iron determination in fortified flours using thymol-1,10-phenanthroline deep eutectic solvent and smartphone-based digital image photometry [0.03%]
一种锅铁强化面粉测定法，使用丁香酚-1,10菲啰啉深吴溶剂和基于智能手机的数字图像光度计
Samara Soares,Maria C Hespanhol,Fábio R P Rocha
Samara Soares
Iron fortification of flours is an important public health strategy for reducing iron-deficiency anemia. Conventional procedures for iron determination in fortified flours generally involve acid digestion followed by determination using eit...
A low-cost, high-throughput DNA quantification system using light pipe arrays for parallel fluorescence measurement [0.03%]
一种使用光管阵列进行并行荧光测量的低成本高通量DNA量化系统
Jiandong Zhu,Haojie Sun,Bo Yang et al.
Jiandong Zhu et al.
Accurate DNA concentration measurement is essential for molecular biology, enabling precise quantification and optimization of various experimental protocols. While UV absorbance at 260 nm is common, fluorometric methods using fluorescent d...
Rapid miniaturized electrochemical biosensor based on screen-printed technology for early-stage taurine detection through manganese molybdate nanosheets and bionicimprinted nanofilms [0.03%]
基于荧光屏印刷技术的快速小型化电化学生物传感器，用于通过锰钼纳米片和仿生嵌入式纳米膜进行早期牛磺酸检测
Yudong Sun,Yuanyuan Jin,Yirui Liu et al.
Yudong Sun et al.
Taurine, an important osmotic regulator and neuromodulator in the brain, is widely recognized as a novel biomarker for cardiovascular and neurodegenerative diseases because of its cytoprotective and neuroprotective effects. Therefore, devel...