A green analytical method for identification and quantification of carcinogenic impurity N-nitroso-desformyl riociguat in riociguat formulations by UHPLC-MS/MS
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Riociguat, a vasodilatory drug for treating pulmonary hypertension (PH), might generate a nitrosamine drug substance-related impurity (NDSRI), reported as N-nitroso-desformyl riociguat (NNDFR). NDSRIs are a class of nitrosamine impurities that are specific to ... ...
