Stabilization of a ring-opened rhodamine probe via multi-noncovalent interactions for the dual-mode detection of nitazenes [0.03%]
通过多非共价相互作用稳定开环罗丹明探针以实现硝基烯化合物的双模式检测
Yujie Feng,Yudong Li,Bingbing Zhao et al.
Yujie Feng et al.
Nitazene opioids, representing a potent class of emerging synthetic substances, have emerged as a significant threat to public health and biosafety worldwide. However, due to their chemical inertness and structural diversity, conventional s...
Hexafluoroisopropanol-induced salt-free catanionic surfactant supramolecular solvent for direct immersion single-drop microextraction of sulfonamides and fluoroquinolones in water samples [0.03%]
基于六氟异丙醇的不含盐catanionic表面活性剂超分子溶剂直接浸入单滴微萃取水样中的磺胺类和喹诺酮类抗生素
Keke Huang,Jia Chen,Wending Yao et al.
Keke Huang et al.
A hexafluoroisopropanol (HFIP)-induced salt-free catanionic surfactant supramolecular solvent (SUPRAS)-based direct immersion single-drop microextraction method was developed and coupled with high-performance liquid chromatography-ultraviol...
Application of surface-enhanced Raman spectroscopy in the diagnosis of infectious diseases [0.03%]
表面增强拉曼光谱技术在感染性疾病诊断中的应用进展
Lili Tian,Yanxi Li,Tao Wang et al.
Lili Tian et al.
Surface-enhanced Raman spectroscopy (SERS) is increasingly emerging as a pivotal analytical technique in the field of clinical diagnostics. The diagnosis and monitoring of infectious diseases demand rapid, highly sensitive, and accurate det...
A CHEF-driven fluorescent turn-on probe for sensitive and rapid Al3+ detection in live MDA-MB-231 cells [0.03%]
一种用于敏感快速检测活MDA-MB-231细胞中Al3+的CHEF驱动型荧光探针
Rahul Naskar,Gita Rani Murmu,Subrata Mandal et al.
Rahul Naskar et al.
A novel fluorescent switch (PIMB) has been fabricated through a straightforward Schiff base reaction and exhibits highly selective sensing of Al3+ over other metal ions at physiological pH. Upon gradual and specific addition of Al3+, PIMB d...
Target-to-signal conversion and spatial enrichment cascade boost CRISPR/Cas12a biosensing for trace-level pathogen detection [0.03%]
靶标转信号放大的级联空间富集增强型CRISPR/Cas12a生物传感技术用于痕量病原体检测
Yu Liu,Xudong Yue,Bowen Li et al.
Yu Liu et al.
S. typhimurium is a widely distributed and highly pathogenic Gram-negative bacterium capable of causing outbreaks of foodborne illness through the ingestion of contaminated food. Consequently, the development of a rapid and accurate detecti...
Reaction-induced fluorogenic sensing of benzodiazepines: a 3D-printed smartphone-based device with multivariate RGB optimization [0.03%]
反应引起的氟素生成检测苯二氮平类药物：一种基于智能手机的3D打印设备及其多变量RGB优化
Thiago Alvares Zamaro de Freitas,Matheus Martins Guedes,Camilla Fonseca Silva et al.
Thiago Alvares Zamaro de Freitas et al.
A low-cost fluorimetric platform fabricated by 3D printing was developed for benzodiazepine (BZD) detection using smartphone-based RGB image analysis. The method relies on hypochlorite-induced fluorogenesis of non-emissive BZDs, including c...
Rational design of L-histidine-stabilized fluorescent copper nanoclusters for highly selective and sensitive detection of sunset yellow [0.03%]
L-组氨酸稳定铜纳米团簇的理性设计高选择性高灵敏度检测柠檬黄荧光探针
Xingwu Li,Xiaotian Liu,Lili Yuan et al.
Xingwu Li et al.
Consuming Sunset Yellow (SY) in large quantities poses notable health hazards, creating a critical need for dependable analytical techniques to monitor its presence. In this study, we detail the preparation of highly stable copper nanoclust...
Development of a bioluminescent enzyme immunoassay for glycocholic acid based on a single-chain variable fragment-nanoluciferase fusion [0.03%]
基于单链可变片段-纳米荧光素酶融合蛋白的甘石酸生物发光免疫测定法的研究与发展
Yunping Mu,Huajian Cai,Xindan Zhang et al.
Yunping Mu et al.
As glycocholic acid (GCA) has been recognized as a biomarker for hepatocellular carcinoma (HCC), its detection is crucial for the prevention, diagnosis, and treatment of HCC. With the advantages of being simple, rapid and sensitive, immunoa...
A two-stage signal enhancement method integrating the Gaussian mixture model and adaptive rolling ball technique for ultrasensitive fluorescent immunochromatographic detection [0.03%]
一种基于高斯混合模型和自适应滚动球技术的两阶段信号增强型超灵敏荧光免疫层析检测方法
Qian Bian,Chongwen Wang,Wenlong Bai et al.
Qian Bian et al.
Lateral flow immunochromatographic assays (LFIAs) with fluorescent labels have emerged as powerful analytical tools for point-of-care diagnostics, offering superior sensitivity over conventional colorimetric methods. However, quantitative a...
A pathogen-activated DNAzyme triggers hybridization chain reaction for ultra-sensitive salivary detection of Helicobacter pylori [0.03%]
一种病原体激活的DNAzyme触发杂交链式反应用于幽门螺旋杆菌的超灵敏唾液检测
Qiming Chen,Quanling Dong,Zhengrong Lu et al.
Qiming Chen et al.
Helicobacter pylori infection is a major etiological factor in chronic gastritis, peptic ulcer disease, and gastric cancer, highlighting the demand for sensitive, non-invasive, and operationally simple diagnostic strategies. Herein, we repo...