A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope [0.03%]
一个特异识别内源性逆转录病毒ERV-K-Env的HLA-A*03:01限制性表位的T细胞受体仅限于对其相应表位的识别
Erin E Grundy,Lauren C Shaw,Loretta Wang et al.
Erin E Grundy et al.
Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is freq...
Transposable elements in Drosophila montana from harsh cold environments [0.03%]
来自动物寒冷环境中的Drosophila montana转座元件分析
Mohadeseh S Tahami,Carlos Vargas-Chavez,Noora Poikela et al.
Mohadeseh S Tahami et al.
Background: Substantial discoveries during the past century have revealed that transposable elements (TEs) can play a crucial role in genome evolution by affecting gene expression and inducing genetic rearrangements, amon...
Identification and functional analysis of recent IS transposition events in rhizobia [0.03%]
农杆菌中最近转座的IS元件的鉴定及功能分析
Ezequiel G Mogro,Walter O Draghi,Antonio Lagares et al.
Ezequiel G Mogro et al.
Rhizobia are alpha- and beta- Proteobacteria that, through the establishment of symbiotic interactions with leguminous plants, are able to fix atmospheric nitrogen as ammonium. The successful establishment of a symbiotic interaction is high...
Evolution of Einkorn wheat centromeres is driven by the mutualistic interplay of two LTR retrotransposons [0.03%]
两个长末端重复序列逆转录转座子的互利互作驱动意大利粗穗小麦染色体进化
Matthias Heuberger,Dal-Hoe Koo,Hanin Ibrahim Ahmed et al.
Matthias Heuberger et al.
Background: Centromere function is highly conserved across eukaryotes, but the underlying centromeric DNA sequences vary dramatically between species. Centromeres often contain a high proportion of repetitive DNA, such as...
Transposon-derived introns as an element shaping the structure of eukaryotic genomes [0.03%]
转座子衍生内含子作为塑造真核生物基因组结构的元件
Weronika Mikina,Paweł Hałakuc,Rafał Milanowski
Weronika Mikina
The widely accepted hypothesis postulates that the first spliceosomal introns originated from group II self-splicing introns. However, it is evident that not all spliceosomal introns in the nuclear genes of modern eukaryotes are inherited t...
Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes [0.03%]
系统性红斑狼疮粒细胞中L1逆转座子编码的ORF1p、逆转录产物及DNA感受器的亚细胞定位
Fatemeh Moadab,Sepideh Sohrabi,Xiaoxing Wang et al.
Fatemeh Moadab et al.
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with more stable disease. SLE is characterized by broad immune activation ...
Identification of transposable element families from pangenome polymorphisms [0.03%]
从泛基因组多态性中识别转座元件家族
Pío Sierra,Richard Durbin
Pío Sierra
Background: Transposable Elements (TEs) are segments of DNA, typically a few hundred base pairs up to several tens of thousands bases long, that have the ability to generate new copies of themselves in the genome. Most ex...
Internal initiation of reverse transcription in a Penelope-like retrotransposon [0.03%]
Penelope类反转座子的内部反向转录起始机制
Chris J Frangieh,Max E Wilkinson,Daniel Strebinger et al.
Chris J Frangieh et al.
Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (PLEs), has been well-characteri...
Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse [0.03%]
短L1序列的插入在小鼠中产生跨品系组蛋白乙酰化差异
Beverly Ann G Boyboy,Kenji Ichiyanagi
Beverly Ann G Boyboy
Background: Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements. Since epigenetic modifications regulate gene ex...
Teaching transposon classification as a means to crowd source the curation of repeat annotation - a tardigrade perspective [0.03%]
作为重复注释的众包整理手段的教学：缓步动物视角下的转座子分类
Valentina Peona,Jacopo Martelossi,Dareen Almojil et al.
Valentina Peona et al.
Background: The advancement of sequencing technologies results in the rapid release of hundreds of new genome assemblies a year providing unprecedented resources for the study of genome evolution. Within this context, the...