Teleost genomic repeat landscapes in light of diversification rates and ecology [0.03%]
分化率和生态学视角下的硬骨鱼基因组重复序列景观分析
William B Reinar,Ole K Tørresen,Alexander J Nederbragt et al.
William B Reinar et al.
Repetitive DNA make up a considerable fraction of most eukaryotic genomes. In fish, transposable element (TE) activity has coincided with rapid species diversification. Here, we annotated the repetitive content in 100 genome assemblies, cov...
Pan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity [0.03%]
与LINE-1反向重复序列启动子活性相关的表达基因的泛癌分析
Baohong Xu,Xueer Li,Shaoqi Zhang et al.
Baohong Xu et al.
Background: Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons, L1 may take part in cancer initiation and progression in some ways. The...
Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition [0.03%]
来自mRNA逆转录转座的新型和功能性的miRNAs： Retro-miRs
Rafael L V Mercuri,Helena B Conceição,Gabriela D A Guardia et al.
Rafael L V Mercuri et al.
Background: Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and highly conserved RNA molecules that serve as key post-transcriptional regul...
SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses [0.03%]
SARS-CoV-2感染引起LTR69内源性逆转录病毒亚家族表观遗传变化
Ankit Arora,Jan Eric Kolberg,Smitha Srinivasachar Badarinarayan et al.
Ankit Arora et al.
Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. By analyzing ChIP-sequencing data sets, we show that SARS-CoV-2 infection induces H3...
Zuzana Loubalova,Parthena Konstantinidou,Astrid D Haase
Zuzana Loubalova
PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of germline genomes. In this review, we examine the common elements of piRNA-guided silencing as wel...
Transposable elements as essential elements in the control of gene expression [0.03%]
转座元件作为基因表达调控的重要要素
Alemu Gebrie
Alemu Gebrie
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile elements, make up a significant portion of the genomes of higher animals. TEs contribute in controlling the expression of genes locally and even far...
Reproducible evaluation of transposable element detectors with McClintock 2 guides accurate inference of Ty insertion patterns in yeast [0.03%]
McClintock 2引导的可重复性转座元件检测评价以及酵母Ty插入模式的准确推断
Jingxuan Chen,Preston J Basting,Shunhua Han et al.
Jingxuan Chen et al.
Background: Many computational methods have been developed to detect non-reference transposable element (TE) insertions using short-read whole genome sequencing data. The diversity and complexity of such methods often pre...
Host range of strand-biased circularizing integrative elements: a new class of mobile DNA elements nesting in Gammaproteobacteria [0.03%]
链偏向的闭合整合元件的宿主范围：在肠杆菌门细菌中发现的一种新型可移动遗传元件
Desmila Idola,Hiroshi Mori,Yuji Nagata et al.
Desmila Idola et al.
Background: The strand-biased circularizing integrative elements (SEs) are putatively non-mobilizable integrative elements for transmitting antimicrobial resistance genes. The transposition mode and the prevalence of SEs ...
THE1B may have no role in human pregnancy due to ZNF430-mediated silencing [0.03%]
ZNF430介导的沉默可能使THE1B在人类妊娠中无作用
Zheng Zuo
Zheng Zuo
THE1-family retrovirus invaded the primate genome more than 40 million years ago. Dunn-Fletcher et al. reported one THE1B element upstream of CRH gene alters gestation length by upregulating corticotropin-releasing hormone expression in tra...
Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus [0.03%]
活动性系统性红斑狼疮患者中粒细胞L1逆转座子的表达
Kennedy C Ukadike,Rayan Najjar,Kathryn Ni et al.
Kennedy C Ukadike et al.
Background: Patients with systemic lupus erythematosus (SLE) have autoantibodies against the L1-encoded open-reading frame 1 protein (ORF1p). Here, we report (i) which immune cells ORF1p emanates from, (ii) which L1 loci ...