Internal initiation of reverse transcription in a Penelope-like retrotransposon [0.03%]
Penelope类反转座子的内部反向转录起始机制
Chris J Frangieh,Max E Wilkinson,Daniel Strebinger et al.
Chris J Frangieh et al.
Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (PLEs), has been well-characteri...
Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse [0.03%]
短L1序列的插入在小鼠中产生跨品系组蛋白乙酰化差异
Beverly Ann G Boyboy,Kenji Ichiyanagi
Beverly Ann G Boyboy
Background: Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements. Since epigenetic modifications regulate gene ex...
Teaching transposon classification as a means to crowd source the curation of repeat annotation - a tardigrade perspective [0.03%]
作为重复注释的众包整理手段的教学：缓步动物视角下的转座子分类
Valentina Peona,Jacopo Martelossi,Dareen Almojil et al.
Valentina Peona et al.
Background: The advancement of sequencing technologies results in the rapid release of hundreds of new genome assemblies a year providing unprecedented resources for the study of genome evolution. Within this context, the...
Long-read sequencing improves the genetic diagnosis of retinitis pigmentosa by identifying an Alu retrotransposon insertion in the EYS gene [0.03%]
长读序贯技术通过在EYS基因中鉴定出L1长散在原件插入，提高了对视网膜色素变性的遗传诊断能力
Elena Fernández-Suárez,María González-Del Pozo,Cristina Méndez-Vidal et al.
Elena Fernández-Suárez et al.
Background: Biallelic variants in EYS are the major cause of autosomal recessive retinitis pigmentosa (arRP) in certain populations, a clinically and genetically heterogeneous disease that may lead to legal blindness. EYS...
Look4LTRs: a Long terminal repeat retrotransposon detection tool capable of cross species studies and discovering recently nested repeats [0.03%]
寻找LTRs：一种能够跨物种研究和发现最近插入重复序列的长末端重复逆转录转座子检测工具
Anthony B Garza,Emmanuelle Lerat,Hani Z Girgis
Anthony B Garza
Plant genomes include large numbers of transposable elements. One particular type of these elements is flanked by two Long Terminal Repeats (LTRs) and can translocate using RNA. Such elements are known as LTR-retrotransposons; they are the ...
Multiple horizontal transfer events of a DNA transposon into turtles, fishes, and a frog [0.03%]
多个DNA转座子水平转移事件进入龟类、鱼类和蛙类的染色体中
Nozhat T Hassan,James D Galbraith,David L Adelson
Nozhat T Hassan
Horizontal transfer of transposable elements (HTT) has been reported across many species and the impact of such events on genome structure and function has been well described. However, few studies have focused on reptilian genomes, especia...
RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats [0.03%]
RepEnTools：一个用于ChIP-seq数据的重复富集分析软件包，揭示了hUHRF1串联-Tudor域在年轻重复序列中的富集现象
Michel Choudalakis,Pavel Bashtrykov,Albert Jeltsch
Michel Choudalakis
Background: Repeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read high-throughput sequencing (HTS) data, such as ChIP-seq, is a challenging task....
Orthoptera-TElib: a library of Orthoptera transposable elements for TE annotation [0.03%]
Orthoptera-TElib：用于转座元件注释的Orthoptera可移动元素库
Xuanzeng Liu,Lina Zhao,Muhammad Majid et al.
Xuanzeng Liu et al.
Transposable elements (TEs) are a major component of eukaryotic genomes and are present in almost all eukaryotic organisms. TEs are highly dynamic between and within species, which significantly affects the general applicability of the TE d...
The role of Smarcad1 in retroviral repression in mouse embryonic stem cells [0.03%]
Smarcad1在小鼠胚胎干细胞中对逆转录病毒抑制的作用
Igor Bren,Ayellet Tal,Carmit Strauss et al.
Igor Bren et al.
Background: Moloney murine leukemia virus (MLV) replication is suppressed in mouse embryonic stem cells (ESCs) by the Trim28-SETDB1 complex. The chromatin remodeler Smarcad1 interacts with Trim28 and was suggested to allo...
CRISPR-TE: a web-based tool to generate single guide RNAs targeting transposable elements [0.03%]
CRISPR-TE：一个基于网络的生成针对可转座元件的单导向RNA的工具
Yixin Guo,Ziwei Xue,Meiting Gong et al.
Yixin Guo et al.
Background: The CRISPR/Cas systems have emerged as powerful tools in genome engineering. Recent studies highlighting the crucial role of transposable elements (TEs) have stimulated research interest in manipulating these ...