Transposable element dynamics in glioblastoma stem cells: insights from locus-specific quantification [0.03%]
胶质母细胞瘤干细胞中的转座元件动态变化：来自特定定位定量的见解
Mattia D Pizzagalli,Yusuke Suita,Owen P Leary et al.
Mattia D Pizzagalli et al.
Background: Glioblastoma, the most common primary malignant brain tumor, has a median survival of less than two years. This is due in part to a subpopulation of cells called glioblastoma stem cells (GSCs), which drive tum...
Escherichia coli proteins uL29 and ACP stabilize the Tn7-encoded TnsD and its DNA binding [0.03%]
大肠杆菌蛋白uL29和ACP通过稳定Tn7编码的TnsD及其DNA结合来促进转座作用
Shani B Leyva Camacho,Lindsay A Matthews,Alba Guarné
Shani B Leyva Camacho
Tn7 mobile genetic elements are known for their sophisticated target-site selection mechanisms and, in some cases, programmability. Recognition of target sites is mediated by designated transposon-encoded proteins and modulated by host fact...
A plan or pandemonium? The conundrum of retrotransposon activation in cancer [0.03%]
计划还是混乱？癌症中逆转座子激活的困境
Elina Zueva
Elina Zueva
Locus-specific HERV expression associated with hepatocellular carcinoma [0.03%]
与肝细胞癌相关的HML-2逆转录病毒元件染色体位点特异性表达
Hui Wen,Marcos Pérez-Losada,Lopa Mishra et al.
Hui Wen et al.
Background: Human endogenous retroviruses (HERVs) harbor accessory proteins that influence cellular processes and have been linked to a wide variety of diseases, including cancer. This study investigates locus-specific HE...
Daniel A Murimi-Worstell,Irene B Murimi-Worstell,Farrah M Roy et al.
Daniel A Murimi-Worstell et al.
Background: Human endogenous retroviruses (HERVs) are remnants of ancient viral infections and comprise 6-8% of the human genome. Their biological functions in cancer remain poorly understood, especially in glioblastoma, ...
Exploring transposable elements: new horizons in cancer diagnostics and therapeutics [0.03%]
可移动元件的研究：癌症诊断和治疗的新视野
Ahlam Chaaban,Reem Sleem,Jana Santina et al.
Ahlam Chaaban et al.
Transposable elements (TE), also called transposons, are repetitive DNA sequences making up half of the human genome. Initially, TEs were described as "junk DNA" because they lack specific function. However, they have been recognized for th...
Co-option of an endogenous retrovirus (LTR7-HERVH) in early human embryogenesis: becoming useful and going unnoticed [0.03%]
始发性人类胚胎发育中内源性逆转录病毒(LTR7-HERVH)的征用：转为有用，蒙混过关
Zsuzsanna Izsvák,Jin Ma,Manvendra Singh et al.
Zsuzsanna Izsvák et al.
While it is straightforward to understand why most mutations affecting functional sequence are harmful, how genomic changes result in new beneficial traits is harder to understand. Domestication of transposable elements (TEs) is an importan...
Interaction with eukaryotic cells enhances the circularization and transcription of integrative and conjugative elements in Mycoplasma hominis [0.03%]
与真核细胞的相互作用增强了Mycoplasma hominis中整合和接合元件的环化和转录
Bachir Boureima Abdou,Alicia Silvant,Chloé Le Roy et al.
Bachir Boureima Abdou et al.
Mobile genetic elements drive bacterial evolution by promoting genetic plasticity and adaptation; among them, mycoplasma Integrative and Conjugative Elements (ICEs) challenge the notion that mycoplasmas evolved solely through genome reducti...
The highly diverse repertoire of transposable elements within the genomes of parasitic wasps (Hymenoptera: Braconidae) [0.03%]
寄生小蜂基因组（膜翅目：小蜂科）中高度多样的转座元件库
Rachel N Behm,Barbara J Sharanowski
Rachel N Behm
Transposable elements (TEs) are known to be major components of eukaryotic genomes and impact genome evolution and architecture, including in the speciose lineage of Insecta. Although new and increased efforts have allowed for more insect g...
Double-stranded DNA viruses may serve as vectors for horizontal transfer of intron-generating transposons [0.03%]
双链DNA病毒可能是介导产生内含子转座子的水平基因转移载体
Landen Gozashti,Russell Corbett-Detig
Landen Gozashti
Specialized transposable elements capable of generating introns, termed introners, are one of the major drivers of intron gain in eukaryotes. Horizontal transfer of transposable elements (HTT) is thought to play an important role in shaping...