Mobilizing diversity: transposable element insertions in genetic variation and disease [0.03%]
调动多样性：转座元件插入在遗传变异和疾病中的作用
Kathryn A O&#x;Donnell,Kathleen H Burns
Kathryn A O&#x;Donnell
Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number of these elements are actively jumping in our genomes today. As a consequence, these insertions provide a source of genetic variation and, in rare cases, t...
George Chaconas,Nancy Craig,M Joan Curcio et al.
George Chaconas et al.
An international conference on mobile DNA was held 24-28 April 2010 in Montreal, Canada. Sponsored by the American Society for Microbiology, the conference's goal was to bring together researchers from around the world who study transpositi...
Yi Hou,Jyothi Rajagopal,Phillip A Irwin et al.
Yi Hou et al.
Background: Retrotransposons are abundant components of plant genomes, and although some plant retrotransposons have been used as insertional mutagens, these mobile genetic elements have not been widely exploited for plan...
Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7 [0.03%]
TnsD-attTn7复合体的表征促进了Tn7的特异性插入作用
Rupak Mitra,Gregory J McKenzie,Liang Yi et al.
Rupak Mitra et al.
The bacterial transposon Tn7 is distinguished by its ability to recognize a specific site called attTn7, and insert just downstream of the highly conserved chromosomal glmS gene. TnsD is one of four transposon-encoded polypeptides (TnsABC+D...
Different integration site structures between L1 protein-mediated retrotransposition in cis and retrotransposition in trans [0.03%]
顺式与反式L1蛋白介导的逆转录插入位点的结构差异
Kenji K Kojima
Kenji K Kojima
Background: Long interspersed nuclear element-1 (LINE-1 or L1) is a dominant repetitive sequence in the human genome. Besides mediating its own retrotransposition, L1 can mobilize Alu and messenger RNA (mRNA) in trans, an...
Philippe Rousseau,Catherine Tardin,Nathalie Tolou et al.
Philippe Rousseau et al.
Tight regulation of transposition activity is essential to limit damage transposons may cause by generating potentially lethal DNA rearrangements. Assembly of a bona fide protein-DNA complex, the transpososome, within which transposition is...
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions [0.03%]
非长末端重复序列(LTR)逆转座子：机制、最近的进展和尚未解决的问题
Jeffrey S Han
Jeffrey S Han
Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of en...
Min Zhang,Liza Sz Larsen,Becky Irwin et al.
Min Zhang et al.
Background: The yeast retrotransposon Ty3 forms stable virus-like particles. Gag3, the major structural protein, is composed of capsid, spacer and nucleocapsid domains. The capsid domain of Gag3 was previously modeled as ...
Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1 [0.03%]
基于端粒特异性非长末端重复逆转录转座子TRAS1的EN结构域创建新型端粒切割内切酶
Kazutoshi Yoshitake,Hideyuki Aoyagi,Haruhiko Fujiwara
Kazutoshi Yoshitake
Background: The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating. However, in can...
A subtelomeric non-LTR retrotransposon Hebe in the bdelloid rotifer Adineta vaga is subject to inactivation by deletions but not 5' truncations [0.03%]
拟步甲类转座子Hebe受缺失失活但不受5'端截短影响
Eugene A Gladyshev,Irina R Arkhipova
Eugene A Gladyshev
Background: Rotifers of the class Bdelloidea are microscopic freshwater invertebrates best known for: their capacity for anhydrobiosis; the lack of males and meiosis; and for the ability to capture genes from other non-me...