Marlene Belfort,Luciano Marraffini,Todd Macfarlan et al.
Marlene Belfort et al.
During the Mobile Genetic Elements and Genome Evolution Keystone Symposium in March 2014, the Editors of Mobile DNA caught up with a panel of conference speakers to select key advances in the field, and hear their thoughts on where mobile D...
Blood from 'junk': the LTR chimeric transcript Pu.2 promotes erythropoiesis [0.03%]
由“ Junk”产生的血液：“ junk” DNA中的LTR嵌合转录本Pu.2促进红细胞生成
Kyle R Upton,Geoffrey J Faulkner
Kyle R Upton
Transposable elements (TEs) are a prominent feature of most eukaryotic genomes. Despite rapidly accumulating evidence for the role of TE-driven insertional mutagenesis and structural variation in genome evolution, few clear examples of indi...
The Tc1/mariner transposable element family shapes genetic variation and gene expression in the protist Trichomonas vaginalis [0.03%]
TC1/Mariner转座子家族塑造了阴道毛滴虫中的遗传变异和基因表达
Martina Bradic,Sally D Warring,Vivien Low et al.
Martina Bradic et al.
Background: Trichomonas vaginalis is the most prevalent non-viral sexually transmitted parasite. Although the protist is presumed to reproduce asexually, 60% of its haploid genome contains transposable elements (TEs), kno...
John L Goodier
John L Goodier
LINE-1s (L1s), the only currently active autonomous mobile DNA in humans, occupy at least 17% of human DNA. Throughout evolution, the L1 has also been responsible for genomic insertion of thousands of processed pseudogenes and over one mill...
Francois Sabot
Francois Sabot
Background: Tos17 was the first LTR retrotransposon (Copia) described as active in cultivated rice, and is present in two copies in the genome of the sequenced Nipponbare variety. Only the chromosome 7 copy is active and ...
Visual ModuleOrganizer: a graphical interface for the detection and comparative analysis of repeat DNA modules [0.03%]
视觉模块组织者：识别和比较重复DNA模块的图形界面
Sebastien Tempel,Emmanuel Talla
Sebastien Tempel
Background: DNA repeats, such as transposable elements, minisatellites and palindromic sequences, are abundant in sequences and have been shown to have significant and functional roles in the evolution of the host genomes...
Georg Hausner,Mohamed Hafez,David R Edgell
Georg Hausner
Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially ren...
Homing endonucleases from mobile group I introns: discovery to genome engineering [0.03%]
从可移动的I类内含子中发现同源重组内切酶并应用于基因组工程
Barry L Stoddard
Barry L Stoddard
Homing endonucleases are highly specific DNA cleaving enzymes that are encoded within genomes of all forms of microbial life including phage and eukaryotic organelles. These proteins drive the mobility and persistence of their own reading f...
Whole genome sequencing in Drosophila virilis identifies Polyphemus, a recently activated Tc1-like transposon with a possible role in hybrid dysgenesis [0.03%]
对Drosophila virilis的全基因组测序鉴定出Polyphemus，这是一种最近被激活的Tc1样转座子，并且可能在杂交不育中有一定作用
Justin P Blumenstiel
Justin P Blumenstiel
Background: Hybrid dysgenic syndromes in Drosophila have been critical for characterizing host mechanisms of transposable element (TE) regulation. This is because a common feature of hybrid dysgenesis is germline TE mobil...
Recent advances in in vivo applications of intein-mediated protein splicing [0.03%]
体内蛋白质内含肽裂解的最新研究进展
Natalya I Topilina,Kenneth V Mills
Natalya I Topilina
Intein-mediated protein splicing has become an essential tool in modern biotechnology. Fundamental progress in the structure and catalytic strategies of cis- and trans-splicing inteins has led to the development of modified inteins that pro...