Chicken (Gallus gallus) endogenous retrovirus generates genomic variations in the chicken genome [0.03%]
鸡内源性逆转录病毒造成基因组变异及其分子机制研究
Jinmin Lee,Seyoung Mun,Dong Hee Kim et al.
Jinmin Lee et al.
Background: Transposable elements (TEs) comprise ~10% of the chicken (Gallus gallus) genome. The content of TEs is much lower than that of mammalian genomes, where TEs comprise around half of the genome. Endogenous retrov...
Functional characterization of the active Mutator- like transposable element, Muta1 from the mosquito Aedes aegypti [0.03%]
来源于埃及伊蚊的活性Mutator-like转座元件Muta1的功能表征
Kun Liu,Susan R Wessler
Kun Liu
Background: Mutator-like transposable elements (MULEs) are widespread with members in fungi, plants, and animals. Most of the research on the MULE superfamily has focused on plant MULEs where they were discovered and wher...
Biju Vadakkemukadiyil Chellapan,Peter van Dam,Martijn Rep et al.
Biju Vadakkemukadiyil Chellapan et al.
Background: Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...
The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation [0.03%]
富含内含子的HERV-K(HML-10)族可抑制细胞凋亡，这是恶性转化的一个指标
Felix Broecker,Roger Horton,Jochen Heinrich et al.
Felix Broecker et al.
Background: Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...
Artem Babaian,Dixie L Mager
Artem Babaian
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant expression of coding genes or ...
Deciphering fact from artifact when using reporter assays to investigate the roles of host factors on L1 retrotransposition [0.03%]
揭秘报道试验在研究宿主因子对L1逆转录转座作用中的角色时的事实和人工制品
Pamela R Cook,G Travis Tabor
Pamela R Cook
Background: The Long INterspersed Element-1 (L1, LINE-1) is the only autonomous mobile DNA element in humans and has generated as much as half of the genome. Due to increasing clinical interest in the roles of L1 in cance...
Pragathi Achanta,Jared P Steranka,Zuojian Tang et al.
Pragathi Achanta et al.
Background: Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...
Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme [0.03%]
L1相关的DNA重排证据及glioblastoma multiforme中L1逆转录的微不足道作用
Patricia E Carreira,Adam D Ewing,Guibo Li et al.
Patricia E Carreira et al.
Background: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...
John G Zampella,Nemanja Rodić,Wan Rou Yang et al.
John G Zampella et al.
Background: The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...
Pengjun Xu,Roberto Feuda,Bin Lu et al.
Pengjun Xu et al.
Background: Retrotransposed genes are different to other types of genes as they originate from a processed mRNA and are then inserted back into the genome. For a long time, the contribution of this mechanism to the origin...
Case Reports
Mobile DNA. 2016 Oct 19:7:18. DOI:10.1186/s13100-016-0074-8 2016