Tracing the history of LINE and SINE extinction in sigmodontine rodents [0.03%]
关于_sigmodontine_啮齿动物中LINE和SINE进化消失的历史研究
Lei Yang,LuAnn Scott,Holly A Wichman
Lei Yang
Background: L1 retrotransposons have co-evolved with their mammalian hosts for the entire history of mammals and currently compose ~ 20% of a mammalian genome. B1 retrotransposons are dependent on L1 for retrotranspositio...
MGERT: a pipeline to retrieve coding sequences of mobile genetic elements from genome assemblies [0.03%]
MGERT：从基因组组装中检索移动遗传元件编码序列的流水线方法
Andrei S Guliaev,Seraphima K Semyenova
Andrei S Guliaev
Background: Genomes of eukaryotes are inhabited by myriads of mobile genetic elements (MGEs) - transposons and retrotransposons - which play a great role in genome plasticity and evolution. A lot of computational tools we...
Identification of charged amino acids required for nuclear localization of human L1 ORF1 protein [0.03%]
鉴定人类L1 ORF1蛋白核定位所需的带电氨基酸残基
B T Freeman,M Sokolowski,A M Roy-Engel et al.
B T Freeman et al.
Background: Long Interspersed Element 1 (LINE-1) is a retrotransposon that is present in 500,000 copies in the human genome. Along with Alu and SVA elements, these three retrotransposons account for more than a third of t...
Retrotransposons evolution and impact on lncRNA and protein coding genes in pigs [0.03%]
猪内源逆转录病毒的进化及其对长链非编码RNA和蛋白质编码基因的影响
Cai Chen,Wei Wang,Xiaoyan Wang et al.
Cai Chen et al.
Background: Retrotransposons are the major determinants of genome sizes and they have shaped both genes and genomes in mammalian organisms, but their overall activity, diversity, and evolution dynamics, particularly their...
Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs [0.03%]
表征MOBT家族的解旋酶，该家族广泛存在于厚壁菌门中，可介导ICE转移
Nicolas Soler,Emilie Robert,Isaure Chauvot de Beauchêne et al.
Nicolas Soler et al.
Background: Conjugative spread of antibiotic resistance and virulence genes in bacteria constitutes an important threat to public health. Beyond the well-known conjugative plasmids, recent genome analyses have shown that ...
Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype [0.03%]
嵌合逆转录子序列插入小鼠Axin1基因座可引起不稳定的卷尾表型
Zhuqing Wang,Hayden McSwiggin,Simon J Newkirk et al.
Zhuqing Wang et al.
Background: Transposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns. However, the effects of retrotransposition on the ho...
Human transposons are an abundant supply of transcription factor binding sites and promoter activities in breast cancer cell lines [0.03%]
人转座子是乳腺癌细胞系中转录因子结合位点和启动活性的丰富来源
Jiayue-Clara Jiang,Kyle R Upton
Jiayue-Clara Jiang
Background: Transposable elements (TE) are commonly regarded as "junk DNA" with no apparent regulatory roles in the human genome. However, a growing body of evidence demonstrates that some TEs exhibit regulatory activitie...
Liane Gagnier,Victoria P Belancio,Dixie L Mager
Liane Gagnier
Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situ...
Subtype classification and functional annotation of L1Md retrotransposon promoters [0.03%]
L1Md长末端重复序列启动子的亚型分类及其功能注释
Meng Zhou,Andrew D Smith
Meng Zhou
Background: L1Md retrotransposons are the most abundant and active transposable elements in the mouse genome. The promoters of many L1Md retrotransposons are composed of tandem repeats called monomers. The number of monom...
Transcriptionally promiscuous "blurry" promoters in Tc1/ mariner transposons allow transcription in distantly related genomes [0.03%]
Tc1/马尔纳尔转座子中的“模糊”启动子允许其在远缘基因组中进行转录
Antonio Palazzo,Patrizio Lorusso,Csaba Miskey et al.
Antonio Palazzo et al.
Background: We have recently described a peculiar feature of the promoters in two Drosophila Tc1-like elements, Bari1 and Bari3. The AT-richness and the presence of weak core-promoter motifs make these promoters, that we ...