Type I interferons increase expression of endogenous retrovirus K102 and envelope protein in myeloid cells from patients with autoimmune disease [0.03%]
I型干扰素增加自身免疫疾病患者髓系细胞内源性逆转录病毒K102的表达及其包膜蛋白的产生
Ethan Le,Fatemeh Moadab,Xiaoxing Wang et al.
Ethan Le et al.
Background: Autoantibodies against envelope (Env) protein encoded by human endogenous retrovirus group K (HERV-K) are prevalent in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), but it remains unclear w...
Gene and transposable element expression in response to stress in temperate and tropical populations of Drosophila [0.03%]
果蝇温带和热带种群响应胁迫的基因和转座子表达差异性分析
Miriam Merenciano,Daniel S Oliveira,Judit Salces-Ortiz et al.
Miriam Merenciano et al.
Background: The study of stress response in natural populations is crucial for understanding species local adaptation and evolution. In Drosophila, significant genetic diversity across populations from different geographi...
Comparative structural analysis of IS21 transposition complexes using Cryo-EM and AlphaFold3 [0.03%]
基于Cryo-EM和AlphaFold3的IS21转座复合物结构分析比较
Mercedes Spínola-Amilibia,Irene Rizzuto,Ernesto Arias-Palomo
Mercedes Spínola-Amilibia
Transposition is a fundamental driver of genome evolution, enabling the movement of discrete DNA segments (transposons) within genomes. This process can modulate gene expression and contributes to the spread of antibiotic resistance and vir...
Transposable element dynamics in glioblastoma stem cells: insights from locus-specific quantification [0.03%]
胶质母细胞瘤干细胞中的转座元件动态变化：来自特定定位定量的见解
Mattia D Pizzagalli,Yusuke Suita,Owen P Leary et al.
Mattia D Pizzagalli et al.
Background: Glioblastoma, the most common primary malignant brain tumor, has a median survival of less than two years. This is due in part to a subpopulation of cells called glioblastoma stem cells (GSCs), which drive tum...
Escherichia coli proteins uL29 and ACP stabilize the Tn7-encoded TnsD and its DNA binding [0.03%]
大肠杆菌蛋白uL29和ACP通过稳定Tn7编码的TnsD及其DNA结合来促进转座作用
Shani B Leyva Camacho,Lindsay A Matthews,Alba Guarné
Shani B Leyva Camacho
Tn7 mobile genetic elements are known for their sophisticated target-site selection mechanisms and, in some cases, programmability. Recognition of target sites is mediated by designated transposon-encoded proteins and modulated by host fact...
A plan or pandemonium? The conundrum of retrotransposon activation in cancer [0.03%]
计划还是混乱？癌症中逆转座子激活的困境
Elina Zueva
Elina Zueva
Locus-specific HERV expression associated with hepatocellular carcinoma [0.03%]
与肝细胞癌相关的HML-2逆转录病毒元件染色体位点特异性表达
Hui Wen,Marcos Pérez-Losada,Lopa Mishra et al.
Hui Wen et al.
Background: Human endogenous retroviruses (HERVs) harbor accessory proteins that influence cellular processes and have been linked to a wide variety of diseases, including cancer. This study investigates locus-specific HE...
Daniel A Murimi-Worstell,Irene B Murimi-Worstell,Farrah M Roy et al.
Daniel A Murimi-Worstell et al.
Background: Human endogenous retroviruses (HERVs) are remnants of ancient viral infections and comprise 6-8% of the human genome. Their biological functions in cancer remain poorly understood, especially in glioblastoma, ...
Exploring transposable elements: new horizons in cancer diagnostics and therapeutics [0.03%]
可移动元件的研究：癌症诊断和治疗的新视野
Ahlam Chaaban,Reem Sleem,Jana Santina et al.
Ahlam Chaaban et al.
Transposable elements (TE), also called transposons, are repetitive DNA sequences making up half of the human genome. Initially, TEs were described as "junk DNA" because they lack specific function. However, they have been recognized for th...
Co-option of an endogenous retrovirus (LTR7-HERVH) in early human embryogenesis: becoming useful and going unnoticed [0.03%]
始发性人类胚胎发育中内源性逆转录病毒(LTR7-HERVH)的征用：转为有用，蒙混过关
Zsuzsanna Izsvák,Jin Ma,Manvendra Singh et al.
Zsuzsanna Izsvák et al.
While it is straightforward to understand why most mutations affecting functional sequence are harmful, how genomic changes result in new beneficial traits is harder to understand. Domestication of transposable elements (TEs) is an importan...