Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective [0.03%]
致病性和非致病性酵母模型中的多样化转座元件景观：比较视角的价值
Patrick H Maxwell
Patrick H Maxwell
Genomics and other large-scale analyses have drawn increasing attention to the potential impacts of transposable elements (TEs) on their host genomes. However, it remains challenging to transition from identifying potential roles to clearly...
AcademH, a lineage of Academ DNA transposons encoding helicase found in animals and fungi [0.03%]
AcademH：一类在动物和真菌中发现的编码解旋酶的Academ DNA转座子谱系
Kenji K Kojima
Kenji K Kojima
Background: DNA transposons are ubiquitous components of eukaryotic genomes. Academ superfamily of DNA transposons is one of the least characterized DNA transposon superfamilies in eukaryotes. DNA transposons belonging to...
Variation in base composition underlies functional and evolutionary divergence in non-LTR retrotransposons [0.03%]
基组成变化导致非LTR长散在核元件的功能分化和进化变异
Robert P Ruggiero,Stéphane Boissinot
Robert P Ruggiero
Background: Non-LTR retrotransposons often exhibit base composition that is markedly different from the nucleotide content of their host's gene. For instance, the mammalian L1 element is AT-rich with a strong A bias on th...
The UCSC repeat browser allows discovery and visualization of evolutionary conflict across repeat families [0.03%]
UCSC重复浏览器允许发现并可视化跨重复家族的进化冲突
Jason D Fernandes,Armando Zamudio-Hurtado,Hiram Clawson et al.
Jason D Fernandes et al.
Background: Nearly half the human genome consists of repeat elements, most of which are retrotransposons, and many of which play important biological roles. However repeat elements pose several unique challenges to curren...
Integrated Mobile Element Scanning (ME-Scan) method for identifying multiple types of polymorphic mobile element insertions [0.03%]
整合型移动元件扫描（ME-Scan）方法，用于鉴定多种多态性可移动元件插入类型
Jui Wan Loh,Hongseok Ha,Timothy Lin et al.
Jui Wan Loh et al.
Background: Mobile elements are ubiquitous components of mammalian genomes and constitute more than half of the human genome. Polymorphic mobile element insertions (pMEIs) are a major source of human genomic variation and...
Finding and extending ancient simple sequence repeat-derived regions in the human genome [0.03%]
寻找和扩展人类基因组中的古同源简单序列重复区
Jonathan A Shortt,Robert P Ruggiero,Corey Cox et al.
Jonathan A Shortt et al.
Background: Previously, 3% of the human genome has been annotated as simple sequence repeats (SSRs), similar to the proportion annotated as protein coding. The origin of much of the genome is not well annotated, however, ...
Hybrid dysgenesis in Drosophila virilis results in clusters of mitotic recombination and loss-of-heterozygosity but leaves meiotic recombination unaltered [0.03%]
丛养果蝇的杂交退化导致了有丝分裂重组和杂合性丧失的簇群但未影响减数分裂重组
Lucas W Hemmer,Guilherme B Dias,Brittny Smith et al.
Lucas W Hemmer et al.
Background: Transposable elements (TEs) are endogenous mutagens and their harmful effects are especially evident in syndromes of hybrid dysgenesis. In Drosophila virilis, hybrid dysgenesis is a syndrome of incomplete gona...
Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines [0.03%]
人内源性逆转录病毒(HERV)衍生的肿瘤相关抗原的特征：富含RNA-seq分析在套细胞淋巴瘤细胞系中的HERV-K(HML-2)
Witold Tatkiewicz,James Dickie,Franchesca Bedford et al.
Witold Tatkiewicz et al.
Background: The cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. The human genome contains ...
Alexandros Bousios,Hans-Wilhelm Nützmann,Dorothy Buck et al.
Alexandros Bousios et al.
Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is stil...
Editorial
Mobile DNA. 2020 Feb 4:11:8. DOI:10.1186/s13100-020-0202-3 2020
LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites [0.03%]
LUMI-PCR：一种用于整合位点克隆的illumina平台连接介导pcr协议，可对整合位点进行分子定量
Joanna C Dawes,Philip Webster,Barbara Iadarola et al.
Joanna C Dawes et al.
Background: Ligation-mediated PCR protocols have diverse uses including the identification of integration sites of insertional mutagens, integrating vectors and naturally occurring mobile genetic elements. For approaches ...