Zebrafish models of acute leukemias: Current models and future directions [0.03%]
急性白血病斑马鱼模型：当前模式和未来方向
Brandon Molina,Jasmine Chavez,Stephanie Grainger
Brandon Molina
Acute myeloid leukemias (AML) and acute lymphoid leukemias (ALL) are heterogenous diseases encompassing a wide array of genetic mutations with both loss and gain of function phenotypes. Ultimately, these both result in the clonal overgrowth...
Anoohya N Muppirala,Lauren E Limbach,Elisabeth F Bradford et al.
Anoohya N Muppirala et al.
Vertebrate nervous system function requires glial cells, including myelinating glia that insulate axons and provide trophic support that allows for efficient signal propagation by neurons. In vertebrate peripheral nervous systems, neural cr...
Human pluripotent stem cell-derived lung organoids: Potential applications in development and disease modeling [0.03%]
人多能干细胞来源的肺类器官：在发育和疾病建模中的潜在应用
Lu Tian,Jinghui Gao,Irving M Garcia et al.
Lu Tian et al.
The pulmonary system is comprised of two main compartments, airways and alveolar space. Their tissue and cellular complexity ensure lung function and protection from external agents, for example, virus. Two-dimensional (2D) in vitro systems...
Viraat Y Goel,Anders S Hansen
Viraat Y Goel
The 3D organization of the genome facilitates gene regulation, replication, and repair, making it a key feature of genomic function and one that remains to be properly understood. Over the past two decades, a variety of chromosome conformat...
Hongjie Li
Hongjie Li
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating cell states and functions at the single-cell level. It has greatly revolutionized transcriptomic studies in many life science research fields, such as n...
Proximity-dependent labeling methods for proteomic profiling in living cells: An update [0.03%]
活细胞蛋白质组分析的邻近依赖标记方法：最新进展
Justin A Bosch,Chiao-Lin Chen,Norbert Perrimon
Justin A Bosch
Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. Proximity labeling-based methods coupled with m...
Edel Alvarez-Ochoa,Francesca Froldi,Louise Y Cheng
Edel Alvarez-Ochoa
Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct si...
Alberto Rosello-Diez
Alberto Rosello-Diez
Network-regulated organ allometry: The developmental regulation of morphological scaling [0.03%]
网络调控的器官全ometry：形态尺度发展的调节
Isabelle M Vea,Alexander W Shingleton
Isabelle M Vea
Morphological scaling relationships, or allometries, describe how traits grow coordinately and covary among individuals in a population. The developmental regulation of scaling is essential to generate correctly proportioned adults across a...
Integrating levels of bone growth control: From stem cells to body proportions [0.03%]
整合骨骼生长控制层次：从干细胞到身体比例
Brett J Kagan,Alberto Rosello-Diez
Brett J Kagan
The study of the mechanisms controlling organ size during development and regeneration is critical to understanding how complex life arises from cooperating single cells. Long bones are powerful models in this regard, as their size depends ...