Aldosterone synthase inhibitors for the treatment of cardiovascular disease [0.03%]
醛固酮合酶抑制剂在心血管疾病治疗中的应用
Gian Paolo Rossi,Federico Bernardo Rossi,Andrea Cignarella et al.
Gian Paolo Rossi et al.
Aldosterone is essential for maintaining blood pressure during hypovolaemia and/or dehydration through genomic actions mediated by the mineralocorticoid receptor and rapid signalling pathways involving the G-protein-coupled oestrogen recept...
Causes and consequences of discontinuation of GLP1RAs or tirzepatide [0.03%]
GLP-1受体激动剂或 tirzepatide 治疗的停止原因及其后果
Antonio Ceriello,Francesco Prattichizzo,Abdul Raouf Mastan Sheik Abdullah et al.
Antonio Ceriello et al.
Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists and tirzepatide, a dual GLP1R and glucose-dependent insulinotropic polypeptide receptor agonist, have become fundamental in managing type 2 diabetes mellitus (T2DM) and obesity due to...
The pathogenesis and intersecting mechanisms of monogenic bone mass disorders [0.03%]
单基因骨量障碍的发病机制及交叉作用机制分析
Raja Padidela,Gretl Hendrickx,Geert Mortier et al.
Raja Padidela et al.
Monogenic disorders of bone mass arise from variants in single genes disrupting the intricate processes of bone formation and resorption. Genes underlying bone mass disorders are involved in various intersecting molecular mechanisms in cell...
Sobha Sivaprasad,Stela Vujosevic
Sobha Sivaprasad
Diabetic retinopathy has traditionally been defined as a microvascular complication of diabetes mellitus; however, advances in retinal imaging, digital technologies and mechanistic insights have challenged this narrow view. Increasing evide...
Clinical obesity in Asian people: bridging the gap between adiposity and disease [0.03%]
临床肥胖与亚洲人体脂和疾病之间的关系桥梁理论
Soo Lim,Linong Ji,Kwang Wei Tham et al.
Soo Lim et al.
This Perspective argues for a reconceptualization of clinical obesity in Asian populations, moving beyond BMI-centric definitions towards an adiposity-based and function-based framework. Asian populations exhibit a distinctive obesity pheno...
Olivia Tysoe
Olivia Tysoe
Julien Paccou,Elena Tsourdi,Athanasios D Anastasilakis et al.
Julien Paccou et al.
Age-related decline in sex hormones is the most frequent cause of primary osteoporosis; however, secondary causes contribute to osteoporosis in a substantial proportion of cases. These causes are diverse and often overlooked, ranging from e...
Precision medicine in low-income settings and small island developing states [0.03%]
低收入地区和小岛屿发展中国家的精准医疗
Sushant Saluja,Fahmida Mannan,Guillaume Pare et al.
Sushant Saluja et al.
Precision medicine tailors prevention, diagnosis and treatment of cardiometabolic diseases to individual genetic, environmental and lifestyle determinants, with the potential to fundamentally change healthcare. However, low-income and middl...
The effect of hypoglycaemia on neurodevelopment: insights from congenital hyperinsulinism [0.03%]
低血糖对神经发育的影响：先天性高胰岛素血症的启示
Pamela Bowman,Jonna M E Männistö,Sarah E Flanagan
Pamela Bowman
NKX6.1 expression is linked to successful pancreatic islet transplantation [0.03%]
NKX6.1的表达与成功的胰岛移植相关
Senegal Carty
Senegal Carty