Endocannabinoids and related lipids in host metabolism-gut microbiome signalling [0.03%]
内源大麻素和相关脂质在宿主代谢-肠道微生物组信号传导中的作用
Cristoforo Silvestri,Vincenzo Di Marzo
Cristoforo Silvestri
Over the past two decades, it has become clear that the two endocannabinoids, anandamide and 2-arachidonoyl-glycerol, are only the tip of an iceberg of a larger signalling system composed of hundreds of chemically similar fatty acid derivat...
mRNA-LNP therapeutics for obesity: weight loss with metabolic repair [0.03%]
用于治疗肥胖的mRNA-LNP疗法：兼具减重和代谢修复功能
Jun Liao,Lukas Farbiak,Daniel J Siegwart et al.
Jun Liao et al.
Leonardo V M de Assis,Richard M Blay,Madilyn Coles et al.
Leonardo V M de Assis et al.
Claes Ohlsson,Lina Lawenius,Louise Grahnemo et al.
Claes Ohlsson et al.
As populations age worldwide, the incidence of fractures is increasing, leading to considerable disease burden and increased health-care costs. Bone mineral density (BMD), bone quality and muscle function are major contributors to fracture ...
Claire Greenhill
Claire Greenhill
Therapeutic potential of targeting the orexin (hypocretin) system in sleep disorders [0.03%]
靶向食欲素（下丘脑分泌素）系统治疗睡眠障碍的潜力
Birgitte R Kornum,Alberte Wollesen Breum,Zuzanna Mincikiewicz et al.
Birgitte R Kornum et al.
Sleep is emerging as a key health topic in modern society. The prevalence of and focus on sleep-wake disorders is increasing, which has led to a large interest from the pharmaceutical industry to develop new treatments targeting sleep biolo...
Anastasia Sclocco,Wenya Yang,Laura Ventura et al.
Anastasia Sclocco et al.
Osteogenesis imperfecta is a common genetic disorder of syndromic bone fragility manifesting in types with variable skeletal and extraskeletal severity. Over the past decades, the deforming types have almost exclusively received all scienti...