Mitochondrial uncoupling therapy reduces established atherosclerosis in mice [0.03%]
线粒体解偶联治疗可减少小鼠动脉粥样硬化病情发展
Irene Fernández-Ruiz
Irene Fernández-Ruiz
Cardioprotective properties of empagliflozin and other SGLT2 inhibitors [0.03%]
恩格列净和其他SGLT2抑制剂的心脏保护作用
Thomas A Zelniker,Eugene Braunwald
Thomas A Zelniker
Since the publication of the landmark EMPA-REG OUTCOME trial, sodium-glucose cotransporter 2 (SGLT2) inhibitors have redefined the therapeutic landscape of cardiovascular-kidney-metabolic disease. Initially developed as glucose-lowering dru...
The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing [0.03%]
心脏的四维核ome：发育、疾病和衰老过程中的核和染色质动态变化
Yinuo Wang,Gergana Dobreva
Yinuo Wang
The nucleus is a highly organized and dynamic organelle, with hierarchical layers ranging from nucleosome positioning to chromatin domains and higher-order 3D genome topology. Viewed over time as the 4D nucleome, this organization enables p...
The renaissance of cardiac glycosides in heart failure: why, for whom and when [0.03%]
心脏糖苷在心力衰竭中的复兴：为什么、用于哪些患者以及何时使用
Antonio Cannata,Theresa A McDonagh
Antonio Cannata
Ghulam Mehdi Dar
Ghulam Mehdi Dar
In the era of AI, omics and organoids, animal models are still needed in cardiovascular research [0.03%]
在人工智能、组学和类器官时代，心血管研究仍需动物模型
Petra Kleinbongard,Bruno K Podesser,Gemma Vilahur et al.
Petra Kleinbongard et al.
World Heart Federation Roadmap on cardiac rehabilitation: a pathway to lifelong cardiovascular health [0.03%]
世界心脏联盟心脏康复路线图：终身心血管健康之路
Julie Redfern,Randal J Thomas,Tom Briffa et al.
Julie Redfern et al.
With an ageing population and the persistence of unhealthy lifestyle behaviours, health-care systems are challenged by a growing number of individuals living longer with cardiovascular disease and its sequelae. The evolution of cardiac reha...
Sarcomere dysfunction as the molecular basis of hypertrophic cardiomyopathy [0.03%]
肥厚型心肌病的 sarcomere 功能障碍分子机制
Saif F Dababneh,Thomas M Roston
Saif F Dababneh
Transfer of a gain-of-function PCSK9 gene to induce atherosclerosis in mice [0.03%]
导入功能获得型PCSK9基因诱导小鼠动脉粥样硬化形成
Julián Albarrán-Juárez
Julián Albarrán-Juárez
Epidemiology and determinants of cardiovascular disease in Indigenous populations [0.03%]
印第安人群中的心血管疾病的流行病学及决定因素
Katharine Frances Brown,Victor M Oguoma,Anna Rolleston et al.
Katharine Frances Brown et al.
This Review describes the burden of cardiovascular disease across Indigenous populations and contextualizes the potential drivers and contributors to inequalities between Indigenous and non-Indigenous populations. The focus is on Indigenous...