TLR7 in systemic lupus erythematosus: genetics and emerging therapies [0.03%]
系统性红斑狼疮中的 TLR7：遗传学和新兴疗法
Carola G Vinuesa,Madhumita Shrotri,Anisur Rahman
Carola G Vinuesa
Systemic lupus erythematosus (SLE) is a disease with considerable unmet treatment needs. Endosomal nucleic acid sensing by Toll-like receptor 7 (TLR7) is emerging as a key pathogenic pathway. Gain-of-function mutations in the genes encoding...
Elisabeth Bendstrup,Philippe Dieude,Michael Kreuter et al.
Elisabeth Bendstrup et al.
Rheumatoid arthritis (RA) is a prevalent chronic systemic autoimmune inflammatory disease that primarily targets synovial joints and periarticular tissues. In RA, systemic inflammation has been associated with extra-articular manifestations...
Diagnostic, prognostic and therapeutic biomarkers in rheumatoid arthritis [0.03%]
类风湿关节炎的诊断、预后及治疗生物标志物
Zoltán Szekanecz,Lilla Gunkl-Tóth,Szilvia Szamosi et al.
Zoltán Szekanecz et al.
Outcomes in rheumatoid arthritis (RA) have improved considerably with the advent of new therapeutic modalities, improved therapeutic strategies and greater recognition of the need to manage comorbidities. Nevertheless, unmet needs remain. S...
Thomas V Guy,Matthew J S Parker
Thomas V Guy
Dennis McGonagle,Daniel L Kastner,Ivona Aksentijevich
Dennis McGonagle
Rebecca T Brooks,Bryant R England,Vanessa L Kronzer et al.
Rebecca T Brooks et al.
Rheumatoid arthritis (RA) is associated with a wide spectrum of comorbidities that substantially influence quality of life and long-term outcomes. These include extra-articular manifestations, cardiovascular disease, cerebrovascular acciden...
Rethinking early-stage knee osteoarthritis beyond radiography [0.03%]
超越放射ographs重新思考早期膝骨关节炎阶段 Knee Osteoarthritis Beyond Radiography at the Early Stage
Armaghan Mahmoudian,Ida K Haugen
Armaghan Mahmoudian
Holly Webster
Holly Webster
Decoding variants of uncertain significance in systemic autoinflammatory diseases [0.03%]
解读系统性自身炎症性疾病中的意义未明变异
Guilaine Boursier,Alessandra Carbone,Sinisa Savic et al.
Guilaine Boursier et al.
The development and implementation of genetic testing has revolutionized the diagnostic landscape of autoinflammatory diseases, leading to an exponential increase in the identification of disease-associated genetic variants. Yet a substanti...