H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine [0.03%]
受精卵中H3K9me2通过吸引PGC7防止Tet3介导的5-甲基胞嘧啶氧化
Piroska E Szabó,Gerd P Pfeifer
Piroska E Szabó
Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus. Recent work has shown that the maternal genome i...
Chenhuan Xu,Xiaowen Lu,Eric Z Chen et al.
Chenhuan Xu et al.
DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage [0.03%]
DNA损伤时由ATM / ATR介导的DBC1磷酸化抑制SIRT1去乙酰酶活性
Laura Zannini,Giacomo Buscemi,Ja-Eun Kim et al.
Laura Zannini et al.
Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA damage, competitively inhibits the NAD(+)-dependent deacetylase SIRT1, a regulator of p53 apoptotic functions in response to genotoxic stress. D...
Josep Rizo,Michael K Rosen,Kevin H Gardner
Josep Rizo
The investigation of molecular mechanisms is a fascinating area of current biological research that unites efforts from scientists with very diverse expertise. This review provides a perspective on the characterization of protein interactio...
Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase [0.03%]
原钙粘蛋白簇和细胞黏附素依赖的激酶通过RHO GTP酶调节树突复杂度
Lun Suo,Huinan Lu,Guoxin Ying et al.
Lun Suo et al.
Dendritic patterning and spine morphogenesis are crucial for the assembly of neuronal circuitry to ensure normal brain development and synaptic connectivity as well as for understanding underlying mechanisms of neuropsychiatric diseases and...
Xingqiao Xie,Xiaojie Yan,Zheng Wang et al.
Xingqiao Xie et al.
The amyloid-β protein precursor (APP) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Knock-out and transgenic mouse studies of the adaptor protein Mint2 have revealed that it is a major player in regulating APP metab...
SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype [0.03%]
SOX2使肠道上皮细胞的命运向胃的发育途径转变
Lalini Raghoebir,Elvira R M Bakker,Jason C Mills et al.
Lalini Raghoebir et al.
Various factors play an essential role in patterning the digestive tract. During development, Sox2 and Cdx2 are exclusively expressed in the anterior and the posterior parts of the primitive gut, respectively. However, it is unclear whether...
Ning Cai,Mo Li,Jing Qu et al.
Ning Cai et al.
The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional...
Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes [0.03%]
五聚蛋白-3血清水平与胰岛素抵抗相关，并可预测2型糖尿病的发生
Haibing Chen,Junxi Lu,Xie Chen et al.
Haibing Chen et al.
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis [0.03%]
重编程激活药物活化的p53调控网络以促进肿瘤发生而非抑制肿瘤发生
Wei Song,Jiguang Wang,Ying Yang et al.
Wei Song et al.
Many of oncogenes and tumor suppressor genes have been found to exert variable and even opposing roles in different kinds of tumors or at different stages of cancer development. Here we showed that tumorigenic potential of mouse embryonic c...