MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts [0.03%]
MAPC培养条件支持从骨髓和囊胚中分离出具有新生下胚层特征的细胞
Antonio Lo Nigro,Martine Geraerts,Tineke Notelaers et al.
Antonio Lo Nigro et al.
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways [0.03%]
SIAH2和DYRK2互调节控制缺氧和致突变信号通路
Moisés Pérez,Carmen García-Limones,Inés Zapico et al.
Moisés Pérez et al.
The ubiquitin E3 ligase SIAH2 is an important regulator of the hypoxic response as it leads to the ubiquitin/proteasomal degradation of prolyl hydroxylases such as PHD3, which in turn increases the stability of hypoxia-inducible factor (HIF...
Jiarui Wu
Jiarui Wu
Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis [0.03%]
比较表达谱分析鉴定了Myogenin和p38αMAPK信号在肌细胞生成中的不同作用
Qi-Cai Liu,Xiao-Hui Zha,Hervé Faralli et al.
Qi-Cai Liu et al.
Skeletal muscle differentiation is mediated by a complex gene expression program requiring both the muscle-specific transcription factor Myogenin (Myog) and p38α MAPK (p38α) signaling. However, the relative contribution of Myog and p38α ...
SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis [0.03%]
SUV39H1通过调控着丝粒甲基化动态有序性在有丝分裂中对于精确的染色体分离起关键作用
Lingluo Chu,Tongge Zhu,Xing Liu et al.
Lingluo Chu et al.
Histone methylation performs multiple functions such as DNA replication, transcription regulation, heterochromatin formation, and chromatin condensation. How this methylation gradient is orchestrated in the centromere during chromosome segr...
Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155 [0.03%]
肿瘤相关巨噬细胞向炎性M1表型的再极化由微小核糖核酸-155介导
Xing Cai,Yuan Yin,Ningzhu Li et al.
Xing Cai et al.
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells [0.03%]
针对前列腺癌干细胞/前体细胞与非干非前体细胞中差异雄激素信号通路的新型治疗方法研究
Soo Ok Lee,Zhifang Ma,Chiuan-Ren Yeh et al.
Soo Ok Lee et al.
The androgen deprivation therapy (ADT) to systematically suppress/reduce androgens binding to the androgen receptor (AR) has been the standard therapy for prostate cancer (PCa); yet, most of ADT eventually fails leading to the recurrence of...
Tamaki Suganuma,Jerry L Workman
Tamaki Suganuma
Signal transduction pathways alter the gene expression program in response to extracellular or intracellular cues. Mitogen-activated protein kinases (MAPKs) govern numerous cellular processes including cell growth, stress response, apoptosi...
Song Guo Zheng
Song Guo Zheng
Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome [0.03%]
多克隆CD4+Foxp3+Treg细胞通过TGF-β依赖的方式诱导耐受型树突状细胞从而抑制狼疮样综合征
Qin Lan,Xiaohui Zhou,Huimin Fan et al.
Qin Lan et al.
Interplay between Foxp3(+) regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are not well understood. We report that polyclonal CD4(+)Foxp3(+) Treg cells induced e...