Functional and structural characterization of DNMT2 from Spodoptera frugiperda [0.03%]
家蚕DNMT2的功能和结构研究
Sisi Li,Jiamu Du,Hui Yang et al.
Sisi Li et al.
Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells [0.03%]
分化人子宫内膜间充质细胞中诱导microRNA抗性和分泌
Kunal M Shah,Jason Webber,Raffaella Carzaniga et al.
Kunal M Shah et al.
Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies [0.03%]
高通量技术揭示动物中全基因组选择性多腺苷酸化的新见解
Yu Sun,Yonggui Fu,Yuxin Li et al.
Yu Sun et al.
Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis...
Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer [0.03%]
基于 shotgun 和靶向蛋白质组学的术前血清蛋白标志物可进一步优化 I-IV 期肺鳞癌患者的预后
Yan-Sheng Liu,Xiao-Yang Luo,Qing-Run Li et al.
Yan-Sheng Liu et al.
Jiarui Wu
Jiarui Wu
Mediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasis [0.03%]
中介物MED15调节转化生长因子β（TGFβ）/Smads信号传导和乳腺癌细胞转移
Meng Zhao,Xu Yang,Yu Fu et al.
Meng Zhao et al.
HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop [0.03%]
HIPK2激酶活性依赖于其激活环的顺式自磷酸化作用
Vera V Saul,Laureano de la Vega,Maja Milanovic et al.
Vera V Saul et al.
The multitude of mechanisms regulating the activity of protein kinases includes phosphorylation of amino acids contained in the activation loop. Here we show that the serine/threonine kinase HIPK2 (homeodomain-interacting protein kinase 2) ...
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1 [0.03%]
miR-148a/152和DNMT1在IGF-IR和IRS1调节细胞转化和肿瘤血管生成的调控环路中的作用
Qing Xu,Yue Jiang,Yu Yin et al.
Qing Xu et al.
Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation of miR-148a and miR-152 and their impact on BC cells. Due to the hypermethylation of CpG island, the e...
Activation of the ATM-Snail pathway promotes breast cancer metastasis [0.03%]
ATM-Snail信号通路活化可促进乳腺癌转移
Mianen Sun,Xiaojing Guo,Xiaolong Qian et al.
Mianen Sun et al.
The DNA damage response (DDR) is critical for the maintenance of genetic stability and serves as an anti-cancer barrier during early tumorigenesis. However, the role of the DDR in tumor progression and metastasis is less known. Here, we dem...
Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3 [0.03%]
DEAF1功能下降通过抑制Eif4g3在I型糖尿病中抑制淋巴结成纤维细胞的翻译
Linda Yip,Remi J Creusot,Cara T Pager et al.
Linda Yip et al.
The transcriptional regulator deformed epidermal autoregulatory factor 1 (DEAF1) has been suggested to play a role in maintaining peripheral tolerance by controlling the transcription of peripheral tissue antigen genes in lymph node stromal...