Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3 [0.03%]
Nanog通过下调胸腺素β4和Rnd3抑制细胞迁移
Yizhuo Zhou,Shanshan Li,Qiongping Huang et al.
Yizhuo Zhou et al.
Nanog, Sox2, and Oct4 are key transcription factors critical for the pluripotency and self-renewal of embryonic stem (ES) cells. Their downregulations lead to differentiation, accompanied with changes in cell motility. Whether these factors...
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair [0.03%]
组蛋白H4去乙酰化促进53BP1介导的DNA损伤信号转导和双链断裂修复
Kuei-Yang Hsiao,Craig A Mizzen
Kuei-Yang Hsiao
53BP1 and other DNA damage response (DDR) proteins form foci at double-strand breaks (DSBs) which promote their repair by nonhomologous end joining (NHEJ). Focal accumulation of 53BP1 depends on the specific interaction of its tandem Tudor ...
Xingwu Wang,Xiaocheng Zhao,Xiang Gao et al.
Xingwu Wang et al.
Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation [0.03%]
Akt2敲除通过恢复肥胖诱导的心脏自噬体成熟来维持心脏功能
Xihui Xu,Yinan Hua,Sreejayan Nair et al.
Xihui Xu et al.
TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway [0.03%]
肿瘤坏死因子α通过Akt和Smad3信号通路损害自身免疫性疾病中TGF-β诱导的Treg细胞的分化及功能
Qi Zhang,Feifei Cui,Lei Fang et al.
Qi Zhang et al.
Deficiency in the TGF-β-induced regulatory T (iTreg) cell differentiation is associated with compromised immune homeostasis and plays a key role in many autoimmune diseases. Therapeutic intervention to enhance in situ iTreg differentiation...
CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress [0.03%]
细胞适应辐射压力的应答中cyclinb1/cdk1对线粒体抗氧化蛋白mnsod的磷酸化作用
Demet Candas,Ming Fan,Danupon Nantajit et al.
Demet Candas et al.
Manganese superoxide dismutase (MnSOD), a major antioxidant enzyme within the mitochondria, is responsible for the detoxification of free radicals generated by cellular metabolism and environmental/therapeutic irradiation. Cell cycle-depend...
Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain [0.03%]
结构研究揭示人Rev1蛋白聚合酶互作结构域调节绕过合成聚合酶的机制
Dinan Liu,Kyoung-Seok Ryu,Junsang Ko et al.
Dinan Liu et al.
New march towards the regeneration of sensation and cognition: hear more, see more and learn more [0.03%]
感知与认知再生的新长征：听懂、看透、想开
Kejing Zhang,Fei Yi,Guang-Hui Liu et al.
Kejing Zhang et al.
As many human sensory and cognitive diseases are caused by irreversible damage or loss of certain types of neurons, methodologies aimed at replacement of lost neurons are key to restore lost sensation. Recent advances in generation of ear-c...
New clues for organogenesis [0.03%]
器官发生的新线索
Jiarui Wu
Jiarui Wu