Control of regulatory T cells and T helper cells in human diseases: from bench to bedside [0.03%]
论从实验室到临床：调控调节性T细胞和辅助性T细胞的人类疾病研究
Xiaohui Zhou,Bin Li,Huimin Fan et al.
Xiaohui Zhou et al.
NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion [0.03%]
NG2/CSPG4-VI型胶原蛋白相互作用可能参与肿瘤植入和局部扩张的微环境控制
Sabrina Cattaruzza,Pier Andrea Nicolosi,Paola Braghetta et al.
Sabrina Cattaruzza et al.
In soft-tissue sarcoma patients, enhanced expression of NG2/CSPG4 proteoglycan in pre-surgical primary tumours predicts post-surgical metastasis formation and thereby stratifies patients into disease-free survivors and patients destined to ...
Wen-Chin Yang,Ge Ma,Shu-Hsia Chen et al.
Wen-Chin Yang et al.
Myeloid-derived suppressor cells (MDSC) have recently emerged as one of the central regulators of the immune system. In recent years, interest in understanding MDSC biology and applying MDSC for therapeutic purpose has exploded exponentiall...
Jiarui Wu
Jiarui Wu
New way to tumor therapeutics [0.03%]
肿瘤治疗新思路
Jiarui Wu
Jiarui Wu
RAVER1 is a coactivator of MDA5-mediated cellular antiviral response [0.03%]
Raver1是MDA5介导的细胞抗病毒反应共激活因子
He Chen,Ying Li,Jing Zhang et al.
He Chen et al.
Detection of viral nucleic acids by pattern recognition receptors initiates type I interferon (IFN) induction and innate antiviral response. The RIG-I-like receptors (RLRs), including RIG-I and MDA5, recognize cytoplasmic viral RNA in most ...
A calreticulin/gC1qR complex prevents cells from dying: a conserved mechanism from arthropods to humans [0.03%]
一种钙网蛋白/gC1q受体复合物可防止细胞死亡：从节肢动物到人类的一种保守机制
Apiruck Watthanasurorot,Pikul Jiravanichpaisal,Kenneth Söderhäll et al.
Apiruck Watthanasurorot et al.
The crossroad between cell death and proliferation is a general target for viral infections because viruses need to obstruct apoptosis to use cells for their own replication. Inducing immunogenic cell death in proliferating cells is also an...
Adam P Carroll,Paul A Tooney,Murray J Cairns
Adam P Carroll
Since their discovery, microRNAs (miRNA) have been implicated in a vast array of biological processes in animals, from fundamental developmental functions including cellular proliferation and differentiation, to more complex and specialized...
RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury [0.03%]
RORγt+IL-17+中性粒细胞在肝脏缺血再灌注损伤中的关键作用
Zhongming Tan,Runqiu Jiang,Xuehao Wang et al.
Zhongming Tan et al.
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription [0.03%]
Parkin通过直接调控其启动子转录来不同地调节早老素1和早老素2的功能
Eric Duplan,Jean Sevalle,Julien Viotti et al.
Eric Duplan et al.
We previously established that besides its canonical function as E3-ubiquitin ligase, parkin also behaves as a transcriptional repressor of p53. Here we show that parkin differently modulates presenilin-1 and presenilin-2 expression and fun...