Frontier of life science [0.03%]
生命科学的前沿
Jiarui Wu
Jiarui Wu
The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer [0.03%]
IκB家族成员Bcl-3通过稳定c-Myc在结直肠癌中起致癌作用
Zhanjie Liu,Yuhang Jiang,Yinyong Hou et al.
Zhanjie Liu et al.
Yiren Qin,Jiangwei Lin,Chikai Zhou et al.
Yiren Qin et al.
FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis [0.03%]
面肩肱型肌营养不良症区域基因1与Suv4-20h1组蛋白甲基转移酶结合并阻碍肌细胞分化
Maria Victoria Neguembor,Alexandros Xynos,Maria Cristina Onorati et al.
Maria Victoria Neguembor et al.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy with a strong epigenetic component. It is associated with deletion of a macrosatellite repeat leading to over-expression of the nearby genes. Among them, we foc...
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells [0.03%]
Cbl-b通过下调原发性T细胞的抑制性SMAD7来介导TGFβ敏感性
Thomas Gruber,Reinhard Hinterleitner,Natascha Hermann-Kleiter et al.
Thomas Gruber et al.
T cell-intrinsic transforming growth factor β (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate the sensitivity of T cells to TGFβ; however, the mec...
Jiarui Wu
Jiarui Wu
Soluble Aβ oligomer-induced synaptopathy: c-Jun N-terminal kinase's role [0.03%]
可溶性Aβ寡聚体诱导的突触损伤：c-Jun氨基末端激酶的作用
Alessandra Sclip,Andrea Arnaboldi,Isabella Colombo et al.
Alessandra Sclip et al.
Activation-dependent plasticity of polarized GPCR distribution on the neuronal surface [0.03%]
激活依赖的极化G蛋白偶联受体在神经元细胞表面分布可塑性
Anne C Simon,Claude Loverdo,Anne-Lise Gaffuri et al.
Anne C Simon et al.
Directionality of information flow through neuronal networks is sustained at cellular level by polarized neurons. However, specific targeting or anchoring motifs responsible for polarized distribution on the neuronal surface have only been ...
Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells [0.03%]
细胞间通过细胞外囊泡转移基因组DNA是一种新颖的遗传影响机制
Jin Cai,Yu Han,Hongmei Ren et al.
Jin Cai et al.
Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA...
Anja Solberg,Adam B Robertson,Jan Magnus Aronsen et al.
Anja Solberg et al.
Mammals have nine homologues of the Escherichia coli AlkB repair protein: Alkbh1-8, and the fat mass and obesity associated protein FTO. In this report, we describe the first functional characterization of mouse Alkbh7. We show that the Alk...