Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice [0.03%]
Tex101通过影响小鼠精子迁移进入输卵管而对雄性生育能力起关键作用
Wei Li,Xue-Jiang Guo,Fei Teng et al.
Wei Li et al.
ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast [0.03%]
芽抱酵母中ESCRT组分通过Rim101/Nrg1信号通路调控内质网/高尔基体钙泵基因PMR1的表达
Yunying Zhao,Jingcai Du,Bing Xiong et al.
Yunying Zhao et al.
The endosomal sorting complex required for transport (ESCRT) complexes function to form multivesicular bodies for sorting of proteins destined for the yeast vacuole or the mammalian lysosome. ESCRT components are well conserved in eukaryote...
CTCF depletion alters chromatin structure and transcription of myeloid-specific factors [0.03%]
CTCF缺失可改变髓系特异性因素的染色质结构和转录作用
Lylia Ouboussad,Sarah Kreuz,Pascal F Lefevre
Lylia Ouboussad
Differentiation is a multistep process tightly regulated and controlled by complex transcription factor networks. Here, we show that the rate of differentiation of common myeloid precursor cells increases after depletion of CTCF, a protein ...
Abhishek Harichandan,Kavitha Sivasubramaniyan,Jörg Hennenlotter et al.
Abhishek Harichandan et al.
Connective tissue growth factor is a new ligand of epidermal growth factor receptor [0.03%]
连接组织生长因子是表皮生长因子受体的新配体
Sandra Rayego-Mateos,Raquel Rodrigues-Díez,Jose Luis Morgado-Pascual et al.
Sandra Rayego-Mateos et al.
Chronic kidney disease is reaching epidemic proportions worldwide and there is no effective treatment. Connective tissue growth factor (CCN2) has been suggested as a risk biomarker and a potential therapeutic target for renal diseases, but ...
Heterogeneity of Ca2+ handling among and within Golgi compartments [0.03%]
高尔基复合体不同区室之间的钙离子处理异质性及各区室内部的钙离子处理异质性
Andrea K C Wong,Paola Capitanio,Valentina Lissandron et al.
Andrea K C Wong et al.
The Golgi apparatus (GA) is a dynamic intracellular Ca(2+) store endowed with complex Ca(2+) homeostatic mechanisms in part distinct from those of the endoplasmic reticulum (ER). We describe the generation of a novel fluorescent Ca(2+) prob...
Hanna Appelqvist,Petra Wäster,Katarina Kågedal et al.
Hanna Appelqvist et al.
Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior. They are central for degradation and recycling of macromolecules delivered by endocytosis, phagocytosis, and autophagy. In contrast to the rather simp...
Inhibition of breast cancer local relapse by targeting p70S6 kinase activity [0.03%]
通过抑制p70S6激酶活性来抑制乳腺癌局部复发
Ilenia Segatto,Stefania Berton,Maura Sonego et al.
Ilenia Segatto et al.
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease [0.03%]
阿尔茨海默病的隐藏面：CCR2+单核细胞缺陷
Gaëlle Naert,Serge Rivest
Gaëlle Naert
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by intracellular neurofibrillary tangle formation and extracellular amyloid-β (Aβ) deposition. To date, microglia seem to act as double-edged swords, being either bene...
Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells [0.03%]
新发现的CD8+Foxp3-CD103+ 调节性T细胞的功能和表型特征
Ya Liu,Qin Lan,Ling Lu et al.
Ya Liu et al.
TGF-β and Foxp3 expressions are crucial for the induction and functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8(+) cells display much lower Foxp3 expression, their suppre...