Restoration of intrahepatic regulatory T cells through MMP-9/13-dependent activation of TGF-β is critical for immune homeostasis following acute liver injury [0.03%]
急性肝损伤后通过MMP-9/13依赖的TGF-β活化恢复肝脏内调节性T细胞是免疫稳态的关键因素
Ling Lu,Min Feng,Jia Gu et al.
Ling Lu et al.
During the acute liver injury, immune responses are provoked into eliciting inflammation in the acute phase. In the healing phase, the inflammation is terminated for wound healing and restoration of immune homeostasis. In this study, we sou...
Jiarui Wu
Jiarui Wu
A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth [0.03%]
肝癌亚群通过建立特定胆固醇代谢途径促进肿瘤生长
Ming Lu,Xi-Han Hu,Qin Li et al.
Ming Lu et al.
The liver plays a central role in cholesterol homeostasis. It exclusively receives and metabolizes oxysterols, which are important metabolites of cholesterol and are more cytotoxic than free cholesterol, from all extrahepatic tissues. Hepat...
Thromboxane A2 receptor α promotes tumor growth through an autoregulatory feedback pathway [0.03%]
血栓素A2受体α通过自调节反馈途径促进肿瘤生长
Run-Yue Huang,Ming-Yue Li,Calvin S H Ng et al.
Run-Yue Huang et al.
Tobacco smoking can cause a number of cancers. The role of thromboxane synthase (TxAS) in smoking-related cancers is largely unknown. In this study, 37 pairs of tumor and non-tumor lung tissues of non-small-cell lung cancer, 5 lung cancer c...
The regulation and deregulation of Wnt signaling by PARK genes in health and disease [0.03%]
帕金森基因在健康和疾病状态下对Wnt信号的调控作用
Daniel C Berwick,Kirsten Harvey
Daniel C Berwick
Wingless/Int (Wnt) signaling pathways are signal transduction mechanisms that have been widely studied in the field of embryogenesis. Recent work has established a critical role for these pathways in brain development, especially of midbrai...
Weiyi Liu,Shihuan Kuang
Weiyi Liu
A role for paralog-specific sumoylation in histone deacetylase 1 stability [0.03%]
组蛋白去乙酰化酶1稳定性的泛素特异性甲基化作用
Simona Citro,Ellis Jaffray,Ronald T Hay et al.
Simona Citro et al.
Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific mo...
E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B [0.03%]
E2F1通过VEGF-C/VEGFR-3轴促进血管生成，形成正反馈回路以协同诱导PDGF-B
David Engelmann,Deborah Mayoli-Nüssle,Christian Mayrhofer et al.
David Engelmann et al.
Angiogenesis is essential for primary tumor growth and metastatic dissemination. E2F1, frequently upregulated in advanced cancers, was recently shown to drive malignant progression. In an attempt to decipher the molecular events underlying ...
Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach [0.03%]
化学诱导多能干细胞(CiPSCs)：无转基因方案
Shigeo Masuda,Jun Wu,Tomoaki Hishida et al.
Shigeo Masuda et al.
Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming s...
Jiarui Wu
Jiarui Wu