Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease [0.03%]
Wnt信号在中脑多巴胺能神经元发育及帕金森病再生医学中的作用
Ernest Arenas
Ernest Arenas
Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens to activate several signaling pathways, leading to remodeling of the cytoskeleton and the regulation of gene transcription. Wnt signaling regulates m...
Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease [0.03%]
靶向Wnt信号在神经免疫界面以实现多巴胺能神经保护/修复治疗帕金森病
Francesca L&#x;Episcopo,Cataldo Tirolo,Salvo Caniglia et al.
Francesca L&#x;Episcopo et al.
During the past three decades, the Wingless-type MMTV integration site (Wnt) signaling cascade has emerged as an essential system regulating multiple processes in developing and adult brain. Accumulating evidence points to a dysregulation o...
Effective gene targeting in rabbits using RNA-guided Cas9 nucleases [0.03%]
用于兔基因定位的RNA引导的Cas9内切酶的有效性研究
Dongshan Yang,Jie Xu,Tianqing Zhu et al.
Dongshan Yang et al.
Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection [0.03%]
一种古老的与活跃感染相关的富含于血清中的小RNA的鉴定和表征
Yunfang Zhang,Ying Zhang,Junchao Shi et al.
Yunfang Zhang et al.
ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution [0.03%]
ZIP-seq：单碱基分辨率的三核苷酸重复序列全基因组定位映射技术
Xingxing Xu,Yonghui Tao,Xing Fu et al.
Xingxing Xu et al.
Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease [0.03%]
调节Wnt信号通路以改善帕金森病的细胞替代疗法
Clare L Parish,Lachlan H Thompson
Clare L Parish
Clinical trials have demonstrated the capacity for dopamine neurons, transplanted ectopically into the striatum, to structurally integrate, restore dopamine transmission, and induce long-term functional benefits for Parkinson's disease (PD)...
Drosophila protein phosphatase V regulates lipid homeostasis via the AMPK pathway [0.03%]
果蝇蛋白磷酸酶V通过AMPK途径调控脂质稳态
Dingzi Yin,Ping Huang,Jiarui Wu et al.
Dingzi Yin et al.
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development [0.03%]
Wnt1调控的遗传学网络在中脑多巴胺能神经元发育中的作用
Wolfgang Wurst,Nilima Prakash
Wolfgang Wurst
Neurons synthesizing the neurotransmitter dopamine exert crucial functions in the mammalian brain. The biggest and most important population of dopamine-synthesizing neurons is located in the mammalian ventral midbrain (VM), and controls an...
Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis [0.03%]
中脑多巴胺能神经元决定和神经发生中的Wnt/β-catenin信号通路
Milan Joksimovic,Rajeshwar Awatramani
Milan Joksimovic
Loss of midbrain dopaminergic (mDA) neurons underlies the motor symptoms of Parkinson's disease. Towards cell replacement, studies have focused on mechanisms underlying embryonic mDA production, as a rational basis for deriving mDA neurons ...
The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism [0.03%]
结构研究：Rap1与RIAM复合物的结构决定了特异性和募集机制
Hao Zhang,Yu-Chung Chang,Mark L Brennan et al.
Hao Zhang et al.
The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rap1-interacting adaptor molecule (RIAM). Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyper...