A nomogram to predict gestational diabetes mellitus: a multi-center retrospective study [0.03%]
预测妊娠糖尿病的提法表：一项多中心回顾性研究
Rui Zhang,Zhangyan Li,Nuerbiya Xilifu et al.
Rui Zhang et al.
While gestational diabetes mellitus (GDM) poses great threat to the health of mothers and children, there is no standard early prediction model for this disease yet. This study developed and evaluated a nomogram for predicting GDM in early ...
Guantong Chen,Chenxi Wang,Shuo Huang et al.
Guantong Chen et al.
Ammonia, traditionally recognized as a toxic nitrogen waste product, has recently emerged as a significant player in diverse physiological processes and implicated in cancer biology. This review article provides an overview of the multiface...
Yawen Li,Pingping Li,Yixuan Song et al.
Yawen Li et al.
Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system that is characterized by demyelination, axonal degeneration, and progressive neurological disability and is so far incurable. Current medications are predom...
Argon improves microglia-mediated hippocampal neuronal hyperexcitability to alleviate anxiety-like behaviors in mice [0.03%]
氩气通过改善小胶质细胞介导的海马神经元过度兴奋来缓解焦虑样行为
Jie Cheng,Baiyang Zheng,Shusu Luo et al.
Jie Cheng et al.
The role of inflammation in psychiatric disorders, such as anxiety, has gained increasing attention, with the hippocampus being identified as a key region involved in emotional regulation. Argon has been reported to alleviate the symptoms o...
Comments on 'Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages' [0.03%]
对“波形蛋白中间纤维协调肌动蛋白应力纤维和足小体以确定巨噬细胞对外部基质的分解”的评论
Sandrine Etienne-Manneville
Sandrine Etienne-Manneville
Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity [0.03%]
Septin 6的多价相互作用促进上皮细胞极性的建立
Weihong Fu,Xueying Wang,Mussarat Rafiq et al.
Weihong Fu et al.
Septins, components of the fourth cytoskeleton, play an indispensable role in establishing and maintaining epithelial cell polarity. However, the molecular mechanisms underlying the dynamic assembly of higher-order septin structures and the...
ENO1-BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism [0.03%]
ENO1-BACE2介导的LDLR切割通过重塑胆固醇代谢促进肝癌进展
Zhikun Li,Kaixiang Fan,Caixia Suo et al.
Zhikun Li et al.
Enolase 1 (ENO1) is a glycolytic enzyme involved in tumour progression that performs a variety of classical and nonclassical functions. However, the mechanism by which it promotes tumour progression is still not fully understood. Here, we f...
Low-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion [0.03%]
低剂量奎宁通过作用于KCNH6增强葡萄糖诱导的胰岛素分泌
Feng-Ran Xiong,Juan-Juan Zhu,Xiao-Rong Zhu et al.
Feng-Ran Xiong et al.
Insulin secretion is mainly regulated by two electrophysiological events, depolarization initiated by the closure of ATP-sensitive K+ (KATP) channels and repolarization mediated by K+ efflux. Quinine, a natural component commonly used for t...
METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell [0.03%]
METTL3通过维持Lgr5+干细胞的自我更新和分化来调节结肠上皮完整性
Chenbo Ding,Xinhui Yang,Hua Liu et al.
Chenbo Ding et al.
The development and homeostasis of intestinal epithelium are mediated by actively proliferating Lgr5+ stem cells, which possess a remarkable self-renewal and differentiation capacity. Recently, our study demonstrated that m6A methylation wa...
A long noncoding RNA with enhancer-like function in pig zygotic genome activation [0.03%]
具有增强子样功能的长非编码RNA参与猪合子基因组激活
Renyue Wei,Yanbin Yue,Yinhuan Wu et al.
Renyue Wei et al.
The zygotic genome activation (ZGA) is crucial for the development of pre-implantation embryos. Long noncoding RNAs (lncRNAs) play significant roles in many biological processes, but the study on their role in the early embryonic developmen...