Zhidong He,Na Tang,Hao Liu et al.
Zhidong He et al.
HSF-1 is a highly conserved transcription factor that plays a central role in protecting organisms from diverse cellular stresses. However, the mechanisms by which HSF-1 senses and responds to different types of stress remain incompletely u...
Structural insights into CRL2FEM1C ubiquitin ligase-mediated protein ubiquitination [0.03%]
关于CRL2(FEM1C)泛素连接酶介导的蛋白质泛素化机制的结构洞察
Hualin Zhou,Mor Israel-Gueta,Xinyan Chen et al.
Hualin Zhou et al.
Modelling TIP60-YAP signalling in epithelial cell renewal using 3D gastric organoids [0.03%]
基于胃类器官的上皮细胞更新的TIP60-YAP信号通路建模研究
Hazrat Ismail,Zhen Dou,Dongmei Wang et al.
Hazrat Ismail et al.
Silencing GGH induces autophagy by increasing folate stress and production of NADH [0.03%]
GGH沉默通过增加叶酸胁迫和NADH的产生诱导自噬
Yu Li,Yuhui Du,Sijie Chen et al.
Yu Li et al.
There is an inextricable link between metabolic disorders and autophagy. Gamma-glutamyl hydrolase (GGH) is a lysosomal glycoprotein that reduces intracellular folate stress by catalyzing the hydrolysis of polyglutamylated folate into transp...
Beyond the ends: Potential implications of Telomeric Repeat-Containing RNA (TERRA) for CNS Diseases [0.03%]
端粒之外：端粒重复序列包含的RNA(TERRA)对中枢神经系统疾病的潜在影响
Hadjer Namous,Raghu Vemuganti
Hadjer Namous
Telomeric Repeat-Containing RNA (TERRA) is a class of noncoding RNAs (ncRNAs) emanating from telomeres and control telomere dynamics. Recent studies showed that TERRAs influence chromatin structure and gene expression. TERRAs can also play ...
Characterization of the nucleolar localization signal of TRMT10A and its importance for the m1G9 methylation of tRNAs in mammalian cells [0.03%]
TRMT10A的核仁定位信号特征及其对哺乳动物细胞tRNA的m1G9甲基化的重要性
Tianyang Luo,Zhiyuan Shi,Haibin Yang et al.
Tianyang Luo et al.
Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage [0.03%]
Wnt/β-连环蛋白途径通过AKAP6介导的RyR2磷酸化和肌浆网钙泄漏诱导心脏功能障碍
Ang Li,Yuanyuan Shen,Zhenyan Li et al.
Ang Li et al.
The Wnt signaling pathway plays important roles in cardiomyocyte proliferation and cardiac regeneration after heart injury. Abnormal activation of the Wnt pathway causes a reduction of cardiomyocyte function, leading to hypertrophy, fibrosi...
Calciphylaxis: Ongoing Challenges and Treatment Opportunities with Mesenchymal Stem Cells [0.03%]
钙素化病：间充质干细胞带来的持续挑战和治疗机遇
Daoxu Wu,Shijiu Lu,Jiaying Hu et al.
Daoxu Wu et al.
Calciphylaxis is a rare, progressive disorder characterized by subcutaneous adipose and dermal microvascular calcifications, microthrombi, and endothelial damage. It mainly affects patients with chronic kidney disease (CKD), which is also k...
Chunyue Wang,Jiajia Zhou,Tao Li et al.
Chunyue Wang et al.
Cell migration requires the generation of branched actin networks and recruitment of vesicular membrane that power the protrusion of the plasma membrane in lamellipodia. However, the molecular mechanisms underlying dynamic recruitment of ve...