BAR-PH tandem of ACAP4 remodels membranes to drive migration via Ezrin-dependent activation [0.03%]
ACAP4的BAR-PH串联通过Ezrin依赖性活化驱动迁移的分子机制研究
Shan Huang,Jiasheng Chen,Xinyu Wang et al.
Shan Huang et al.
ADP-ribosylation factor (Arf)-specific GTPase-activating proteins (ArfGAPs) regulate cell migration through interactions with small G proteins, including Arfs. In ArfGAPs, the Bin/Amphiphysin/Rvs (BAR) domain plays a key role in membrane bi...
Association between targeted inflammatory proteomics and insulin sensitivity as well as beta-cell function in subjects with normal glucose tolerance [0.03%]
靶向炎症蛋白组学与正常血糖谱型人群胰岛素敏感性和β细胞功能之间的关系
Anran Chen,Qian Li,Hongfeng Mao et al.
Anran Chen et al.
Obese individuals even with normal glucose tolerance (NGT) are at higher risk for developing type 2 diabetes (T2D), and obesity is associated with inflammation. However, mechanisms linking inflammation to beta-cell function and insulin sens...
MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication [0.03%]
雷帕霉素抑制剂mTORC1通过破坏细胞骨架蛋白中间丝包被小体抵抗登革病毒和寨卡病毒感染
Yuhan Huang,Jiageng Lu,Shuzhi Cui et al.
Yuhan Huang et al.
Flaviviridae Dengue virus (DENV) and Zika virus (ZIKV) have posed significant threats to global public health in the past decades. Despite extensive study on therapeutic strategies against these viruses, effective treatment options are stil...
FOXO1 enhances G6PD expression to promote cancer cell antioxidative capacity [0.03%]
FOXO1通过增强G6PD表达来提高癌细胞抗氧化能力
Xianhong Zhang,Jie Zhang,Mengmeng Wei et al.
Xianhong Zhang et al.
Metabolic adaptability, controlled by transcription factors or oncogenes, is critical for the survival of cancer cells. However, the mechanism by which the transcription factor forkhead box protein O1 (FOXO1) regulates the proliferation and...
TUBA8 promotes neuronal dendrite development through its 40th alanine [0.03%]
TUBA8通过其第40个丙氨酸促进神经元树突发育
Fengxia Shao,Huaqing Xue,Boran Chang et al.
Fengxia Shao et al.
The functional specificity of tubulin isotypes has been demonstrated by various neurological diseases caused by an increasing number of mutations in tubulin isotypes. TUBA8 is specifically localized in cerebellar Purkinje cells, which exhib...
APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation [0.03%]
VHL蛋白介导的泛素化对于内体多囊泡分拣及溶酶体降解是必需的
Chunyan Shan,Rixu Cong,Xiangyu Xu et al.
Chunyan Shan et al.
Amyloid precursor protein (APP), a type I transmembrane protein, is closely related to the pathogenesis of Alzheimer's disease (AD). Amyloid beta (Aβ) is generated by sequential processing of APP in the Golgi apparatus and endosomes, and i...
Regulated cell death in organ transplantation: Recent developments and mechanistic overview [0.03%]
器官移植中的调控细胞死亡：最新研究进展与机制概览
Qian Chen,Jiashi Sun,Shifan Zhu et al.
Qian Chen et al.
Organ transplantation is a definitive therapeutic option for patients with end-stage organ dysfunction and failure. Ischaemia-reperfusion (IR) injury is one of the leading causes of low graft utilisation as it significantly increases the ri...
Automating classification of treatment responses to combined targeted therapy and immunotherapy in HCC [0.03%]
肝癌联合靶向治疗和免疫治疗反应的自动分类
Bing Quan,Mingrong Dai,Peiling Zhang et al.
Bing Quan et al.
Tyrosine kinase inhibitors (TKIs) combined with immunotherapy regimens are now widely used for treating advanced hepatocellular carcinoma (HCC), but their clinical efficacy is limited to a subset of patients. Considering that the vast major...
The tumor-associated fibroblasts regulate urothelial carcinoma progression [0.03%]
肿瘤相关成纤维细胞调节尿路上皮癌进展
Yu Xiao,Junfeng Yang,Mengjie Sun et al.
Yu Xiao et al.
Tumor-associated fibroblasts (CAFs) regulate tumorigenesis, tumor cell proliferation, and metastasis via secreting related regulatory factors; however, the evidence for CAFs in regulating development of upper tract urothelial carcinoma (UTU...
AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming [0.03%]
AMPK通过线粒体自噬诱导的代谢重编程维持肝星状细胞活化
Hanmin Wang,Guanzhen Wang,Tao Yin et al.
Hanmin Wang et al.
The activation of hepatic stellate cells (HSCs), characterized by transdifferentiation from a quiescent state to a fibrogenic phenotype, is a core process of liver fibrosis. The metabolic reprogramming of HSCs plays a major role in this pro...