Slirp2 modulates oogenesis via regulating mitochondrial protein translation [0.03%]
Slirp2通过调节线粒体蛋白翻译调控卵母细胞发生
Jinguo Cao,Jiting Zhang,Zhaoqi Wu et al.
Jinguo Cao et al.
Mitochondria are essential organelles responsible for generating ATP through oxidative phosphorylation (OXPHOS). Despite having their own genome, mitochondria rely on a complex interplay with nuclear-encoded proteins to maintain their funct...
The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt/β-catenin pathway [0.03%]
内向整流型钾通道KCNJ12通过Wnt/β-catenin信号通路调控肝癌干细胞特性
Zihan Zhao,Mixue Bai,Shan Wang et al.
Zihan Zhao et al.
Emerging evidence implicates tumor stemness features-characterized by self-renewal capacity, microenvironment adaptability, and immune evasion mechanisms-as critical determinants of therapeutic resistance and recurrence in hepatocellular ca...
NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis [0.03%]
NAMPT通过SIRT1-C/EBPβ-STEAP4-NRF2轴改善高脂饮食诱导的非酒精性脂肪肝疾病(NAFLD)
Jingwu Zhao,Qinjin Li,Yi Wang et al.
Jingwu Zhao et al.
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic condition, yet therapeutic targets remain elusive. Nicotinamide phosphoribosyl transferase (NAMPT) and six-transmembrane epithelial antigen of the prostate 4 (STEAP4) are integ...
A high-throughput method for quantifying relative telomere length in single cells in situ combined with live-cell imaging [0.03%]
一种高通量量化单个细胞中端粒长度的在体方法，并结合活细胞成像技术
Qingyang Sun,Zhengzhi Zou,Mingwei Min
Qingyang Sun
ZBTB7B inhibits glioma tumorigenicity by upregulating GPR17 and CXCL10 [0.03%]
ZBTB7B通过上调GPR17和CXCL10抑制胶质瘤致癌性
Linmei Zhang,Haozhe Zhang,Chenxi Wang et al.
Linmei Zhang et al.
The transcription factor ZBTB7B has been identified as a potential tumor suppressor through a CRISPR-Cas9-based functional screen of tumor-associated genes, as overexpression of ZBTB7B could significantly suppress tumor growth in the models...
Comments on 'BAF60a-dependent chromatin remodeling preserves β-cell function and contributes to the therapeutic benefits of GLP-1R agonists' [0.03%]
关于“BAF60a依赖的染色质重塑保护β细胞功能并有助于GLP-1受体激动剂治疗益处”的评论
Qingqian Wu,Yue Gao,Zhuo-Xian Meng
Qingqian Wu
Pathogenic Mechanism Underlying Parkinsonism Induced by Neurotoxicants (MPTP and 6-Hydroxydopamine) and α-Synuclein: A Unifying Hypothesis [0.03%]
神经毒素（MPTP和6-羟基多巴胺）和α-突触核蛋白诱导帕金森病的致病机理：统一假设
Bao Ting Zhu
Bao Ting Zhu
The mechanism underlying the selective loss of dopaminergic neurons in Parkinson's disease (PD) is still not understood at present. MPTP, an illicit drug contaminant, can selectively induce parkinsonism in humans and animals which is very s...
Fam3C alters Golgi apparatus morphology and function in triple negative breast cancer [0.03%]
Fam3C改变三阴性乳腺癌中的高尔基体形态和功能
Annamarie C Dalton,Elisabeth R M Rochel,William S Streitfeld et al.
Annamarie C Dalton et al.
Fam3C, also known as Interleukin-like EMT inducer (ILEI), is an established regulator of the epithelial to mesenchymal transition and breast cancer stem cell phenotypes. Multiple cancer cell models and orthotopic animal model experiments ha...
Dynamic crotonylation of Bub3 regulates mitotic checkpoint silencing and chromosome segregation [0.03%]
Bub3的动态克罗屯化调节有丝分裂检查点沉默和染色体分离
Xufan Shi,Xingchen Yu,Wenwen Wang et al.
Xufan Shi et al.
T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis [0.03%]
内皮细胞T-钙粘蛋白缺乏通过SOD2/ROS/NLRP3信号通路介导的焦亡促进川崎病血管损伤
Yueling Lin,Fei Wang,Xilian Luo et al.
Yueling Lin et al.
Kawasaki disease (KD) is an acute febrile systemic vasculitis associated with the development of coronary artery lesion and coronary artery aneurysm. This condition is characterized by sustained vascular inflammation and endothelial dysfunc...