Screening the composition of tubulin isotypes reveals the most abundant TUBB4B for ciliary polarity in ependymal cells [0.03%]
筛选神经上皮细胞中的微管蛋白异构体组成并发现TUBB4B是维持纤毛极性最为丰富的微管蛋白
Yanling Liu,Mingyi Liu,Huaqing Xue et al.
Yanling Liu et al.
Cilia are microtubule-based organelles that protrude from the surface of various eukaryotic cell types. Microtubules are assembled by α/β-tubulin heterodimers, all of which comprise multiple isotypes encoded by distinct genes. However, th...
Cnp1 N-terminal dynamics regulate L1 loop recognition by Mis15 to orchestrate kinetochore assembly in Schizosaccharomyces pombe [0.03%]
酿酒酵母中Cnp1的N端动态调节Mis15对L1环识别以协调芽殖酵母中的着丝粒组装
Yujie Xiong,Yanze Jian,Yongliang Zhang et al.
Yujie Xiong et al.
Centromeres are defined by the histone H3 variant CENP-A, which serve as the foundation for kinetochore assembly and ensure faithful chromosome segregation. CENP-A nucleosomes possess distinctive dynamic features, including flexible DNA end...
CD46 regulates hepatitis B virus entry by modulating cell-surface NTCP levels through cis-interaction [0.03%]
CD46通过顺式相互作用调节细胞表面NTCP水平从而调控乙肝病毒的入侵
Kei Miyakawa,Yusuke Nakai,Taichi Kameya et al.
Kei Miyakawa et al.
Hepatitis B virus (HBV) infection remains a major global health challenge. While sodium taurocholate co-transporting polypeptide (NTCP) is the primary receptor for HBV entry, the molecular mechanisms regulating NTCP-mediated viral entry rem...
Emerging role of FUS in TGFB1 and COL1A1 transcription dependent on GADD45B to induce NASH-fibrosis [0.03%]
GADD45B依赖的FUS在TGFB1和COL1A1转录中的新兴作用，可诱导NASH纤维化
Chi Wu,Qiang Ding,Zhilin Zeng et al.
Chi Wu et al.
Fused in sarcoma (FUS), a DNA-RNA binding protein, affects gene transcription while its role in non-alcoholic steatohepatitis (NASH)-fibrosis is not well understood. In this study, Immunohistochemistry and western blot analysis were used to...
Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice [0.03%]
CCDC92与内鞭毛运输机制相关并能对小鼠的精子生成和雄性生育能力产生影响
Yue Lu,Xirui Zi,Qian Lyu et al.
Yue Lu et al.
The differentiation of a round spermatid into a streamlined sperm cell involves a series of remarkable morphological changes, such as sperm head shaping and flagellum formation. However, the underlying mechanism of spermatid shaping remains...
Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation [0.03%]
Filippi综合征相关基因CKAP2L调控对有丝分裂和纤毛长度调节必不可少的微管动力学
Qian Lyu,Yinghao Wang,Jun Zhou et al.
Qian Lyu et al.
Mutations in the gene encoding cytoskeleton-associated protein 2-like (CKAP2L) have been identified as a causative factor for Filippi syndrome, a rare developmental disorder characterized by facial dysmorphism, syndactyly, and microcephaly....
NOC4L coordinates neuronal and pharyngeal arch development by regulating ribosome biogenesis [0.03%]
NOC4L通过调节核糖体生物发生协调神经元和咽弓发育
Tujing Song,Yan Liu,Yunxiang Zhou et al.
Tujing Song et al.
Mutations in ribosome biogenesis-related genes or functional defects in ribosomal proteins can lead to a class of autosomal genetic disorders characterized by tissue-specific defects, termed ribosomopathies. NOC4L, a critical factor in ribo...
Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways [0.03%]
肿瘤发生蛋白p53N236S通过调节DREAM/MMB和下游端粒DNA复制通路平衡衰老与肿瘤发生
Qianqian Wang,Haili Li,Quan Zheng et al.
Qianqian Wang et al.
The Werner syndrome (WS) is characterized with both premature aging and tumorigenic phenotypes. In this study, we introduced a tumorigenic mutation p53N236S (referred as p53S later), which is found in immortalized WS mouse embryo fibroblast...
Canonical Wnt signaling affects calcium homeostasis in serum-treated AC16 cells through MLN-mediated SERCA2a regulation [0.03%]
canonical Wnt信号通过MLN介导的SERCA2a调控影响血清处理的AC16细胞内的钙稳态
Ang Li,Yuanyuan Shen,Zhenyan Li et al.
Ang Li et al.
The canonical Wnt/β-catenin pathway critically regulates cardiac calcium homeostasis, yet its interplay with microenvironmental factors remains unclear. This study reveals that fetal bovine serum (FBS) treatment alters Wnt-mediated calcium...
Posttranslational modifications in regulating Notch signaling pathway and tumor angiogenesis: from molecular mechanisms to therapeutic applications [0.03%]
表观修饰调控Notch信号通路及肿瘤血管生成的分子机制和转化应用研究获奖标题
Jiaan Wang,Meng Zhang,Donglai Wang
Jiaan Wang
Tumorigenesis exhibits complex interactions with the vascular system. Targeting angiogenesis represents an emerging strategy for remodeling the tumor microenvironment. The Notch signaling pathway, a key regulatory mechanism, orchestrates tu...