Integrated single-nucleus transcriptomic and chromatin accessibility analysis reveals key molecular basis of human testicular aging [0.03%]
整合单核转录组和染色质可及性分析揭示人类睾丸衰老的关键分子机制
Weihao Sun,Hongyu Liu,Pengcheng Pang et al.
Weihao Sun et al.
The human testis, a crucial organ in male reproduction, is mainly responsible for spermatogenesis and androgen production. As men age, testicular function declines, yet the underlying molecular mechanisms are still not well understood. To e...
Energetic metabolic reprogramming in idiopathic pulmonary fibrosis: mechanisms and therapeutics [0.03%]
特发性肺纤维化中的代谢重塑：机制与治疗
Yanlin Zhou,Yuqing Zhang,Shuang Huang et al.
Yanlin Zhou et al.
Sarm1-containing extrachromosomal circular DNA promotes aging-associated cardiac fibrosis via TGF-β/Smad activation [0.03%]
包含Sarm1的细胞外染色体环状DNA通过激活TGF-β/Smad促进与衰老相关的心脏纤维化
Ying Zhang,Siyu Wang,Jie Liu et al.
Ying Zhang et al.
Cardiac aging is associated with progressive cardiac fibrosis and dysfunction, yet the underlying mechanisms remain incompletely understood. Extrachromosomal circular DNA (eccDNA) has been reported to participate in tumor and age-related ge...
Sublytic C5b-9 induces S100A8/A9 expression via SMYD4-dependent SOX7-K159 methylation in the glomerular mesangial cells of Thy-1 nephritis rats [0.03%]
Thy-1肾炎大鼠系膜细胞中次裂解C5b-9通过SMYD4依赖性SOX7-K159甲基化诱导S100A8/A9表达
Yajuan Gong,Mingyu Peng,Yuhua Dong et al.
Yajuan Gong et al.
Rat Thy-1 nephritis (Thy-1 N) is a model for human mesangioproliferative glomerulonephritis (MsPGN). Although sublytic C5b-9 has been reported to affect pro-inflammatory cytokine expression in glomerular mesangial cells (GMCs), the inductio...
Genetically-determined systemic lupus erythematosus requires persistent CAR-T therapy: challenging the transient depletion paradigm [0.03%]
遗传决定的系统性红斑狼疮需要持续的CAR-T治疗：挑战短暂清除范式
Baichuan Liu,Wenchen Ruan,Jingwei Jiang et al.
Baichuan Liu et al.
Long-term management of body weight and physiological mechanisms of weight regain [0.03%]
长期体重管理及体重回升的生理机制
Tingting Hu,Yuqian Bao
Tingting Hu
Overweight and obesity are major global health challenges. Despite progress in behavioral interventions, nutrition, physical activity, pharmacotherapy, and bariatric procedures, weight regain (WR) after successful weight loss is a major cha...
A protein-based prediction model for fragility fracture risk in individuals with diabetes [0.03%]
基于蛋白质的糖尿病个体骨折脆弱性预测模型
Suna Wang,Li Shen,Weituo Zhang et al.
Suna Wang et al.
Individuals with diabetes are at high risk of fragility fractures. We aimed to develop and validate a protein-based model to predict fragility fractures in individuals with diabetes and to explore whether a protein risk score (ProRS) would ...
Unraveling the Mystery of Parathyroid Oxyphil Cells in Uremic SHPT: Ongoing Challenges and Multi-Omics Advances [0.03%]
揭秘慢性肾病继发性甲旁亢嗜酸细胞增多之谜：挑战与组学突破
Jianping Mao,Jing Chen
Jianping Mao
The parathyroid gland, a pivotal organ regulating calcium and phosphorus homeostasis, harbors two primary cell types: chief cells and the enigmatic oxyphil cells. While scarce in healthy individuals, oxyphil cells undergo pronounced prolife...
Xiaoxiao Jia,Guoyun Liu,Haiwen Li et al.
Xiaoxiao Jia et al.
The endoplasmic reticulum (ER) lipid raft proteins (Erlins) belong to the stomatin-prohibitin-flotillin-HflC/K (SPFH) family and form highly oligomeric platforms that mediate the degradation of activated inositol 1,4,5-trisphosphate recepto...
FcεRIγ Reinforces Double-Negative T cell-mediated Antibody-dependent Cellular Cytotoxicity Against Tumor Cells [0.03%]
FcεRIγ增强双阴性T细胞介导的抗体依赖的细胞毒性效应作用于肿瘤细胞中
Shuai Shao,Xiaotong Han,Tianzhen Zhang et al.
Shuai Shao et al.
Double-negative T (DNT) cells (TCRαβ+CD4-CD8-NK1.1-/CD56-) exhibit strong tumor-killing capabilities. Our single-cell transcriptome analysis has revealed high Fcer1g expression in DNT cells, but its role in tumor immunity remains unclear....