Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction [0.03%]
高效的化学诱导小鼠成纤维细胞向功能性的肝细胞转分化
Zhi Zhong,Jiangchuan Du,Xiangjie Zhu et al.
Zhi Zhong et al.
Previous studies have shown that hepatocyte-like cells can be generated from fibroblasts using either lineage-specific transcription factors or chemical induction methods. However, these methods have their own deficiencies that restrict the...
Targeting the PD-L1 cytoplasmic domain and its regulatory pathways to enhance cancer immunotherapy [0.03%]
靶向PD-L1细胞质尾部及其调控通路增强癌症免疫治疗
Fangni Chai,Pan Li,Xin Liu et al.
Fangni Chai et al.
As a significant member of the immune checkpoint, programmed cell death 1 ligand 1 (PD-L1) plays a critical role in cancer immune escape and has become an important target for cancer immunotherapy. Clinically approved drugs mainly target th...
A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4-SMAD3-DNA complex [0.03%]
靶向SMAD4-SMAD3-DNA复合物的多路复用时间分辨荧光共振能量转移超高速筛选检测法
Wukun Ouyang,Qianjin Li,Qiankun Niu et al.
Wukun Ouyang et al.
The transforming growth factor-beta (TGFβ) signaling pathway plays crucial roles in the establishment of an immunosuppressive tumor microenvironment, making anti-TGFβ agents a significant area of interest in cancer immunotherapy. However,...
Corrigendum to 'microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma' [0.03%]
关于“微小核糖核酸-21a-5p/程序性细胞死亡蛋白4轴在间充质干细胞介导的急性青光眼神经保护中的作用”的勘误通知
Wenru Su,Zuohong Li,Yu Jia et al.
Wenru Su et al.
Published Erratum
Journal of molecular cell biology. 2023 Aug 3;15(4):mjad028. DOI:10.1093/jmcb/mjad028 2023
Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+ T regulatory cells [0.03%]
肿瘤坏死因子α/肿瘤坏死因子受体2信号通路的阻断通过减少CCR8+调节性T细胞可抑制结直肠癌并增强抗PD1免疫疗法的效果
Yixian Guo,Feng Xie,Xu Liu et al.
Yixian Guo et al.
Enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been recognized as one of the major factors in the initiation and development of resistance to immune checkpoint inhibitors. C-C motif chemokine receptor 8 (C...
The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm [0.03%]
SARS-CoV-2的特有ORF8蛋白与人类树突状细胞结合并诱导过度炎症性细胞因子风暴
Matthias Hamdorf,Thomas Imhof,Ben Bailey-Elkin et al.
Matthias Hamdorf et al.
The novel coronavirus pandemic, first reported in December 2019, was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection leads to a strong immune response and activation of antigen-presenting cel...
Loss of the vitamin D receptor triggers senescence in chronic myeloid leukemia via DDIT4-mediated DNA damage [0.03%]
维生素D受体的丢失通过DDIT4介导的DNA损伤触发慢性髓系白血病细胞衰老
Yan Xu,Wentao Qi,Chengzu Zheng et al.
Yan Xu et al.
Chronic myeloid leukemia (CML) is a hematopoietic malignancy driven by the fusion gene BCR::ABL1. Drug resistance to tyrosine kinase inhibitors (TKIs), due to BCR::ABL1 mutations and residual leukemia stem cells (LSCs), remains a major chal...
Forty years of HIV research inspires the development of SARS-CoV-2 therapy [0.03%]
艾滋病研究四十年成果助力新冠病毒治疗
Roberto Patarca,William A Haseltine
Roberto Patarca
The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase [0.03%]
BTRC在肝脂肪变性中作为ATGL E3连接酶的关键作用
Weiwei Qi,Zhenzhen Fang,Chuanghua Luo et al.
Weiwei Qi et al.
Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis, is one of the commonest causes of liver dysfunction. Adipose triglyceride lipase (ATGL) is closely related to lipid turnover and hepatic steatosis as the speed-l...
Targeting dysregulated splicing factors in cancer: lessons learned from RBM10 deficiency [0.03%]
靶向癌症中失调的剪接因子：RBM10缺陷得到的启示
Yongbo Wang,Zefeng Wang
Yongbo Wang