JunB condensation attenuates vascular endothelial damage under hyperglycemic condition [0.03%]
高血糖条件下JunB凝聚减弱血管内皮损伤
Xuxia Ren,Zexu Cui,Qiaoqiao Zhang et al.
Xuxia Ren et al.
Endothelial damage is the initial and crucial factor in the occurrence and development of vascular complications in diabetic patients, contributing to morbidity and mortality. Although hyperglycemia has been identified as a damaging effecto...
Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR-Stat3/Akt pathway [0.03%]
Gsdma1/2/3缺失通过抑制EGFR-Stat3/Akt通路缓解PMA诱导的表皮增生
Qiyao Liu,Manyun Li,Minli Sun et al.
Qiyao Liu et al.
Homeostasis of the skin barrier is essential for maintaining normal skin function. Gasdermin A (GSDMA) is highly expressed in the skin and is associated with many skin diseases, such as melanoma and psoriasis. In mice, GSDMA is encoded by t...
The interplay between the muscle and liver in the regulation of glucolipid metabolism [0.03%]
肌肉和肝脏在糖脂代谢调控中的相互作用
Cheng Chen,Liping Xie,Mingliang Zhang et al.
Cheng Chen et al.
Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms [0.03%]
病理相关的戊糖和环境中的醛通过亚胺基团介导的机制引起纤毛解聚
Te Li,Min Liu,Fan Yu et al.
Te Li et al.
Carbohydrate metabolism disorders (CMDs), such as diabetes, galactosemia, and mannosidosis, cause ciliopathy-like multiorgan defects. However, the mechanistic link of cilia to CMD complications is still poorly understood. Herein, we describ...
Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia [0.03%]
受损的dNKAP功能导致果蝇上皮组织基因组不稳定和肿瘤生长
Ting Guo,Chen Miao,Zhonghua Liu et al.
Ting Guo et al.
Mutations or dysregulated expression of NF-kappaB-activating protein (NKAP) family genes have been found in human cancers. How NKAP family gene mutations promote tumor initiation and progression remains to be determined. Here, we characteri...
Jing Zhang,Shu-Guang Yang,Feng-Quan Zhou
Jing Zhang
Glycogen synthase kinase 3 (GSK3) signaling plays important and broad roles in regulating neural development in vitro and in vivo. Here, we reviewed recent findings of GSK3-regulated axon regeneration in vivo in both the peripheral and cent...
Siqi Liu,Jia Xu,Yirui Ai et al.
Siqi Liu et al.
Sex- and age-specific associations between abdominal fat and non-alcoholic fatty liver disease: a prospective cohort study [0.03%]
一项前瞻性队列研究：腹部脂肪与非酒精性肝病的关联具有性别和年龄特异性
Hongli Chen,Yuexing Liu,Dan Liu et al.
Hongli Chen et al.
Obesity is closely related to non-alcoholic fatty liver disease (NAFLD). Although sex differences in body fat distribution have been well demonstrated, little is known about the sex-specific associations between adipose tissue and the devel...
The capsid revolution [0.03%]
衣壳革命
Ian A Taylor,Ariberto Fassati
Ian A Taylor
Lenacapavir, targeting the human immunodeficiency virus type-1 (HIV-1) capsid, is the first-in-class antiretroviral drug recently approved for clinical use. The development of Lenacapavir is attributed to the remarkable progress in our unde...
IDeAS: an interactive database for dysregulated alternative splicing in cancers across Chinese and western patients [0.03%]
IDEA基因失调数据库：中西方癌症病人互作异常剪切失调互动式数据库
Hanwen Zhou,Liyun Yuan,Yuanhu Ju et al.
Hanwen Zhou et al.