Zhikai Wang,Wenwen Wang,Shuaiyu Liu et al.
Zhikai Wang et al.
Although the dynamic instability of microtubules (MTs) is fundamental to many cellular functions, quiescent MTs with unattached free distal ends are commonly present and play important roles in various events to power cellular dynamics. How...
Organization of microtubule plus-end dynamics by phase separation in mitosis [0.03%]
有丝分裂过程中微管正端动力学通过液-液相分离进行组织调控
Fengrui Yang,Mingrui Ding,Xiaoyu Song et al.
Fengrui Yang et al.
In eukaryotes, microtubule polymers are essential for cellular plasticity and fate decisions. End-binding (EB) proteins serve as scaffolds for orchestrating microtubule polymer dynamics and are essential for cellular dynamics and chromosome...
Antiviral factors and their counteraction by HIV-1: many uncovered and more to be discovered [0.03%]
抗病毒因子及其被HIV-1对抗：许多未覆盖的和更多的待发现因素
Dorota Kmiec,Frank Kirchhoff
Dorota Kmiec
Extensive studies on HIV-1 have led to the discovery of a variety of structurally and functionally diverse innate defense factors that target various steps of the retroviral replication cycle. Some of them, such as APOBEC3, tetherin, and SE...
Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern [0.03%]
识别多种值得关注的SARS-CoV-2变异株共有的可药物治疗的宿主依赖因素
Ilaria Frasson,Linda Diamante,Manuela Zangrossi et al.
Ilaria Frasson et al.
The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants, some of which are resistant to vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for viral repli...
Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells [0.03%]
Rbfox1控制心脏肌肉细胞中黏着斑基因的可变剪切
Peter Zorn,Jaime Calvo Sánchez,Tala Alakhras et al.
Peter Zorn et al.
Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein variants. However, it remains challenging to identify physiologically relevant and tissue-selective proteins that are gener...
Inducible RNA targeting and N6-methyladenosine editing by a split-Cas13 architecture [0.03%]
分裂Cas13系统实现的可诱导RNA定位及N6-甲基腺苷编辑
Yang Li,Qiang Sun,Zhi Yang et al.
Yang Li et al.
Aurora B promotes the CENP-T-CENP-W interaction to guide accurate chromosome segregation in mitosis [0.03%]
Aurora B促进CENP-T-CENP-W相互作用以指导有丝分裂中的精确染色体分离
Wei Liu,Zhen Dou,Chunyue Wang et al.
Wei Liu et al.
Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle microtubules. Centromeres are captured by individual microtubules via a kinetochore constitutive centromere-associated network ...
The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development [0.03%]
TRAF7螺旋三聚体的结构为了解其在斑马鱼胚胎发育中的功能提供了线索
Xiaozhen Song,Ruixing Hu,Yi Chen et al.
Xiaozhen Song et al.
TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways, contributing to immune responses, tumor progression, and embryonic development. Somatic mutations within the coiled-coil (CC) ...
Han Yao,Meng Zhang,Donglai Wang
Han Yao
This year marks the fourth decade of research into the protein SET, which was discovered in 1992. SET was initially identified as an oncoprotein, but later, it was shown to be a multifaceted protein involved in regulating numerous biologica...
Raku Son,Kenji Yamazawa,Akiko Oguchi et al.
Raku Son et al.
The living body is composed of innumerable fine and complex structures. Although these structures have been studied in the past, a vast amount of information pertaining to them still remains unknown. When attempting to observe these ultra-s...