Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities [0.03%]
染色体碎裂综合征：从异常有丝分裂到治疗机会的一条新路径
Umer Ejaz,Zhen Dou,Phil Y Yao et al.
Umer Ejaz et al.
Chromothripsis, a type of complex chromosomal rearrangement originally known as chromoanagenesis, has been a subject of extensive investigation due to its potential role in various diseases, particularly cancer. Chromothripsis involves the ...
HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation [0.03%]
HSD17B13液相分离促进慢性肝炎中白细胞黏附
Jing Ye,Xiyu Huang,Manman Yuan et al.
Jing Ye et al.
The rs72613567:TA polymorphism in 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) has been found to reduce the progression from steatosis to nonalcoholic steatohepatitis. In this study, we sought to define the pathogenic role of HSD17B13...
Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis [0.03%]
GLUD1受LASP1和SYVN1介导的抑制对乙肝病毒X蛋白诱导肝癌发生发展的作用
Hong-Juan You,Qi Li,Li-Hong Ma et al.
Hong-Juan You et al.
Glutamate dehydrogenase 1 (GLUD1) is implicated in oncogenesis. However, little is known about the relationship between GLUD1 and hepatocellular carcinoma (HCC). In the present study, we demonstrated that the expression levels of GLUD1 sign...
Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3 [0.03%]
吲哚美辛通过抑制IRF3核转位来限制细胞质核酸刺激的免疫反应
Miao Wang,Xiao-Wei Li,Sen-Chao Yuan et al.
Miao Wang et al.
The recognition of cytosolic nucleic acid triggers the DNA/RNA sensor-IRF3 axis-mediated production of type I interferons (IFNs), which are essential for antiviral immune responses. However, the inappropriate activation of these signaling p...
Comments on 'Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer' [0.03%]
关于“LKB1突变型肺癌中腺癌到鳞癌的转化驱动KRAS抑制耐药”的评论
Xinyuan Tong,Ningxia Zhang,Yun Xue et al.
Xinyuan Tong et al.
Regulation of m6Am RNA modification and its implications in human diseases [0.03%]
m6Am RNA修饰的调控及其在人类疾病中的作用机制研究
Hao Jin,Zhouyuanjing Shi,Tianhua Zhou et al.
Hao Jin et al.
N 6,2'-O-dimethyladenosine (m6Am) is a prevalent modification frequently found at the 5' cap-adjacent adenosine of mRNAs and snRNAs and the internal adenosine of snRNAs. This dynamic and reversible modification is under the regulation of me...
Synergistic regulation of fusion pore opening and dilation by SNARE and synaptotagmin-1 [0.03%]
SNARE和突触素-1对融合孔开放和扩张的协同调节作用
Kaiju Li,Kaiyu Li,Jiaqi Fan et al.
Kaiju Li et al.
Fusion pore opening is a transient intermediate state of synaptic vesicle exocytosis, which is highly dynamic and precisely regulated by the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and synaptota...
Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling [0.03%]
曲美替尼作为细胞骨架波形蛋白重塑调控因子的发现
Shuangshuang Zhao,Zhifang Li,Qian Zhang et al.
Shuangshuang Zhao et al.
The dynamic remodeling of the cytoskeletal network of vimentin intermediate filaments network supports various cellular functions, including cell morphology, elasticity, migration, organelle localization, and resistance against mechanical o...
Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression [0.03%]
代谢组学分析显示妊娠糖尿病进展过程中血清半胱氨酸水平降低
Mengyu Lai,Jiaomeng Li,Jiaying Yang et al.
Mengyu Lai et al.
Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes, but its pathogenesis has not been clearly elucidated. Investigations of the dynamic changes in m...
PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis [0.03%]
PLK1对ZW10的磷酸化指导有丝分裂中染色体的精准分离
Sm Faysal Bellah,Fangyuan Xiong,Zhen Dou et al.
Sm Faysal Bellah et al.
Stable transmission of genetic information during cell division requires faithful chromosome segregation. Mounting evidence has demonstrated that PLK1 dynamics at kinetochores control correct kinetochore-microtubule attachments and subseque...