Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis [0.03%]
人类淋巴系血液生成过程中单细胞的多聚腺苷酸化景观分析
Jiaqi Qiang,Shan Yu,Jun Li et al.
Jiaqi Qiang et al.
Alternative polyadenylation (APA) is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites (PASs). APA is involved in lymphocyte activation; however, its role throughou...
Single-cell analysis defines LGALS1 + fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma [0.03%]
单细胞分析定义了促进肝内胆管癌增殖和迁移的LGALS1+成纤维细胞
Qiqi Cao,Jinxian Yang,Lixuan Jiang et al.
Qiqi Cao et al.
The incidence rate of intrahepatic cholangiocarcinoma (ICC), which has a poor prognosis, is rapidly increasing. To investigate the intratumor heterogeneity of ICC, we analyzed single-cell RNA sequencing data from the primary tumor and adjac...
ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle [0.03%]
ZW10：细胞分裂周期中介导器器官发生的新兴调控因子
Sm Faysal Bellah,Fengrui Yang,Fangyuan Xiong et al.
Sm Faysal Bellah et al.
Zeste white 10 (ZW10) was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila. ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazoans. Recent studies ...
Tao Han,Qian Hao,Tengfei Chao et al.
Tao Han et al.
Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of...
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis [0.03%]
SPIN1通过其IDR发生相分离以促进组蛋白甲基化读取和肿瘤生成
Yukun Wang,Yuhan Chen,Mengyao Li et al.
Yukun Wang et al.
Spindlin1 (SPIN1) is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription, chromosome segregation, and tumorigenesis. However, the function of the extended N-terminal region of SPIN1 has remained...
Marina Mapelli
Marina Mapelli
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production [0.03%]
CCT6A通过抑制HIF-1α介导的乳酸产生缓解肺纤维化
Peishuo Yan,Kun Yang,Mengwei Xu et al.
Peishuo Yan et al.
Idiopathic pulmonary fibrosis (IPF) is a lethal progressive fibrotic lung disease. The development of IPF involves different molecular and cellular processes, and recent studies indicate that lactate plays a significant role in promoting th...
Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality [0.03%]
肾上腺素能信号：乳腺发育和干细胞活力的调控因素
Zi Ye,Yu Xu,Mengna Zhang et al.
Zi Ye et al.
The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal development. Although the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied, t...
The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells [0.03%]
FAcilitates染色质转录复合物调节神经干细胞中糖酵解与氧化磷酸化的比率
Yuhan Lou,Litao Wu,Wanlin Cai et al.
Yuhan Lou et al.
Defects in the FAcilitates Chromatin Transcription (FACT) complex, a histone chaperone composed of SSRP1 and SUPT16H, are implicated in intellectual disability. Here, we reveal that the FACT complex promotes glycolysis and sustains the corr...
Structure-specific nucleases in genome dynamics and strategies for targeting cancers [0.03%]
结构特异性核酸内切酶在基因组动态中的作用及其癌症靶向策略研究进展
Haitao Sun,Megan Luo,Mian Zhou et al.
Haitao Sun et al.
Nucleases are a super family of enzymes that hydrolyze phosphodiester bonds present in genomes. They widely vary in substrates, causing differentiation in cleavage patterns and having a diversified role in maintaining genetic material. Thro...