Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression [0.03%]
替西罗莫司通过抑制FSP1酶活性诱导铁死亡从而抑制肝癌进展
Rui-Lin Tian,Tian-Xiang Wang,Zi-Xuan Huang et al.
Rui-Lin Tian et al.
Ferroptosis is a non-apoptotic mode of cell death characterized by iron-dependent accumulation of lipid peroxidation. While lipid radical elimination reaction catalyzed by glutathione peroxidase 4 (GPX4) is a major anti-ferroptosis mechanis...
Phase separation of hnRNPA1 and TERRA regulates telomeric stability [0.03%]
hnRNPA1和TERRA的相分离调控端粒稳定性
Ziyan Xu,Yongrui Liu,Fudong Li et al.
Ziyan Xu et al.
Telomeres are repetitive DNA sequences and associated protein complexes located at the end of chromatin. As a result of the DNA replication ending issue, telomeric DNA shortens during each cell cycle. The shelterin protein complex caps telo...
Yingcheng Wu,Jiaqiang Ma,Qiang Gao
Yingcheng Wu
Probing centromere-kinetochore core complex CENP-L/M assembly using cenpemlin [0.03%]
利用cenpemlin探究着丝粒-动粒核心复合物CENP-L/M装配
Olanrewaju Ayodeji Durojaye,Fengrui Yang,Xinjiao Gao et al.
Olanrewaju Ayodeji Durojaye et al.
Correction to: Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy [0.03%]
Correction to: 线粒体乙醛脱氢酶通过GSK3β介导的线粒体完整性和Parkin介导的线粒体自噬保护缓解糖尿病心肌病
Published Erratum
Journal of molecular cell biology. 2024 Sep 4:mjae032. DOI:10.1093/jmcb/mjae032 2024
Qingxia Chen,Huijie Zhao,Xinwen Pan et al.
Qingxia Chen et al.
Cilia's back-and-forth beat pattern requires a central pair (CP) of microtubules. However, the mechanism by which the CP is upheld above the transition zone (TZ) remains unclear. Here, we showed that a rod-like substructure marked by Cep131...
Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine [0.03%]
用亚硝基胍使用三维器官样模型胃肠道上皮化生
Yuan Li,Jiena Chen,Tao Li et al.
Yuan Li et al.
Gastric intestinal metaplasia (GIM) represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa, where gastric epithelial cells transform into a phenotype resembling that of intestinal...
Jiaxin Li,Junyan Zhu,Hui Yang et al.
Jiaxin Li et al.
RNA-sensing pathways play a pivotal role in host defense against pathogenic infections to maintain cellular homeostasis. However, in the absence of infection, certain endogenous RNAs can serve as the activators of RNA-sensing pathways as we...
Dual role of PpV in Drosophila crystal cell proliferation and survival [0.03%]
PpV在调控果蝇晶体细胞增殖和存活中的双重作用
Wang Luo,Fang Zhang,Fangzhen Zhao et al.
Wang Luo et al.
Drosophila melanogaster crystal cells are a specialized type of blood cells for innate immune process upon injury. Under normal conditions, crystal cells rarely proliferate and constitute a small proportion of fly blood cells. Notch signali...