Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease [0.03%]
硫氧还蛋白-1通过调节AMPK/Sirt1/PGC1α信号通路促进阿尔茨海默病中的线粒体生物合成
Jinjing Jia,Jiayi Yin,Yu Zhang et al.
Jinjing Jia et al.
Alzheimer's disease (AD) is the most common neurodegenerative disease. Increasing studies suggest that mitochondrial dysfunction is closely related to the pathogenesis of AD. Thioredoxin-1 (Trx-1), one of the major redox proteins in mammali...
Age-Associated Upregulation of Glutamate Transporters and Glutamine Synthetase in Senescent Astrocytes In Vitro and in the Mouse and Human Hippocampus [0.03%]
衰老小胶质细胞中谷氨酸转运体和谷氨酰胺合成酶的表达增加
Isadora Matias,Luan Pereira Diniz,Ana Paula Bergamo Araujo et al.
Isadora Matias et al.
Aging is marked by complex and progressive physiological changes, including in the glutamatergic system, that lead to a decline of brain function. Increased content of senescent cells in the brain, such as glial cells, has been reported to ...
Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration [0.03%]
丙酮酸激酶2可能通过调控能量代谢发挥视网膜保护作用
Jiaming Zhou,Per Ekström
Jiaming Zhou
Retinitis pigmentosa (RP) is an inherited disorder that results in vision impairment but general and mutation-independent therapeutic strategies are not available. However, it is widely regarded that the cGMP system, including cGMP and its ...
Eduardo Morais de Castro,Leonardo Vinícius Barbosa,Aline Simoneti Fonseca et al.
Eduardo Morais de Castro et al.
Central nervous system tumors, especially astrocytomas, are the solid neoplasms with the highest incidence and mortality rates in childhood. The diagnosis is based on histopathological characteristics, but molecular methods have been increa...
Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice [0.03%]
帕金森病模型小鼠中上调的DNA损伤相关生物标志物
Fei Zeng,Karsten Parker,Yanqiang Zhan et al.
Fei Zeng et al.
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indic...
Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice [0.03%]
性别和载脂蛋白E基因型改变人源化定点替换小鼠原代星形胶质细胞的基态和诱导后的炎症状态
Isha Mhatre-Winters,Aseel Eid,Yoonhee Han et al.
Isha Mhatre-Winters et al.
Apolipoprotein E4 (APOE4) genotype and sex are significant risk factors for Alzheimer's disease (AD), with females demonstrating increased risk modulated by APOE genotype. APOE is predominantly expressed in astrocytes, however, there is a l...
Neuroprotection by Preconditioning in Mice is Dependent on MyD88-Mediated CXCL10 Expression in Endothelial Cells [0.03%]
小鼠预处理的神经保护依赖于内皮细胞中MyD88介导的CXCL10表达
Zhihong Chen,Weiwei Hu,Mynor J Mendez et al.
Zhihong Chen et al.
The central nervous system (CNS) can be preconditioned to resist damage by peripheral pretreatment with low-dose gram-negative bacterial endotoxin lipopolysaccharide (LPS). Underlying mechanisms associated with transient protection of the c...
Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases [0.03%]
使用不同的人iPSC分化方法生成的的小胶质细胞培养物在神经退行性疾病模型中的特性比较
Ye Man Tang,Nisha S Pulimood,Stefano Stifani
Ye Man Tang
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nervous system disorders including neurodegener...
Pinky Sultana,Jiri Novotny
Pinky Sultana
Vesicles mediate the trafficking of membranes/proteins in the endocytic and secretory pathways. These pathways are regulated by small GTPases of the Rab family. Rab proteins belong to the Ras superfamily of GTPases, which are significantly ...
Translocation of High Mobility Group Box 1 From the Nucleus to the Cytoplasm in Depressed Patients With Epilepsy [0.03%]
癫痫抑郁症患者高迁移率族蛋白B1从细胞核转移到细胞质中的研究
Xiao-Li Li,Shu Wang,Chong-Yang Tang et al.
Xiao-Li Li et al.
Depression is a common psychiatric comorbidity in patients with epilepsy, especially those with temporal lobe epilepsy (TLE). The aim of this study was to assess changes in high mobility group box protein 1 (HMGB1) expression in epileptic p...