Diverse Responses of Oligodendrocytes to Different FGF-Family Members: Uncoupling Structure-Function Relationship Within FGF Subfamilies [0.03%]
不同FGF家族成员诱导少突胶质细胞产生多样反应：解耦FGF亚家族的结构功能关系
Hebe M Guardiola-Diaz,Brett T DiBenedictis,Erealda Prendaj et al.
Hebe M Guardiola-Diaz et al.
The fifteen canonical paracrine fibroblast growth factors (FGFs) are organized in five subfamilies that interact with four FGF-receptors (FGFRs) and heparan sulfate proteoglycan (HSPG) co-receptors. Many of these FGFs are expressed in CNS r...
An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis [0.03%]
软骨寡聚基质蛋白与多发性硬化患者的脑萎缩和神经退行性变相关联
Intakhar Ahmad,Stig Wergeland,Eystein Oveland et al.
Intakhar Ahmad et al.
Elevated levels of Chitinase-3-like protein-1 (CHI3L1) in cerebrospinal fluid have previously been linked to inflammatory activity and disease progression in multiple sclerosis (MS) patients. This study aimed to investigate the presence of ...
Diazepam Binding Inhibitor Control of Eu- and Hypoglycemic Patterns of Ventromedial Hypothalamic Nucleus Glucose-Regulatory Signaling [0.03%]
戴唑苯胺抑制剂对视上脑室腹内侧核血糖调节信号欧化和低血糖模式的控制作用
Sagor C Roy,Subash Sapkota,Madhu Babu Pasula et al.
Sagor C Roy et al.
Pharmacological stimulation/antagonism of astrocyte glio-peptide octadecaneuropeptide signaling alters ventromedial hypothalamic nucleus (VMN) counterregulatory γ-aminobutyric acid (GABA) and nitric oxide transmission. The current research...
Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance [0.03%]
海马胰岛素受体通过兴奋性/抑制性平衡调节情景记忆和空间记忆
Cai-Yan Xue,Tian Gao,E Mao et al.
Cai-Yan Xue et al.
It is well known that the hippocampus is a vital brain region playing a key role in both episodic and spatial memory. Insulin receptors (InsRs) are densely distributed in the hippocampus and are important for its function. However, the effe...
Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice [0.03%]
烟酸单核苷酸对新生小鼠缺氧缺血性脑损伤的治疗作用
Takuya Kawamura,Gagandeep Singh Mallah,Maryam Ardalan et al.
Takuya Kawamura et al.
Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD+) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotina...
All the PNS is a Stage: Transplanted Bone Marrow Cells Play an Immunomodulatory Role in Peripheral Nerve Regeneration [0.03%]
整个外周神经系统都是一个舞台：移植的骨髓细胞在外周神经再生中发挥免疫调节作用
Gonzalo Piñero,Marianela Vence,Marcos L Aranda et al.
Gonzalo Piñero et al.
Bone marrow cell transplant has proven to be an effective therapeutic approach to treat peripheral nervous system injuries as it not only promoted regeneration and remyelination of the injured nerve but also had a potent effect on neuropath...
Elena Galea,Manuel B Graeber
Elena Galea
Scientific progress requires the relentless correction of errors and refinement of hypotheses. Clarity of terminology is essential for clarity of thought and proper experimental interrogation of nature. Therefore, the application of the sam...
SOD1G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism [0.03%]
SOD1G93A星形胶质细胞来源的外泌体通过miR-155-5P介导机制诱导运动神经元死亡
Soledad Marton,Ernesto Miquel,Joaquín Acosta-Rodríguez et al.
Soledad Marton et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by upper and lower motor neuron (MN) degeneration. Astrocytes surrounding MNs are known to modulate ALS progression. When cocultured with astrocytes over...
The α2 Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice [0.03%]
α2肾上腺素受体激动剂和镇静/麻醉药物右美托咪定能兴奋小鼠下侧视前区的多种神经元类型
Sumei Fan,Xinqi Cheng,Pingping Zhang et al.
Sumei Fan et al.
Dexmedetomidine is an important ICU sedative. The mechanism of dexmedetomidine is not fully understood. Activating NA(-) and NA(+) neurons in the VLPO by dexmedetomidine using polysomnography and electrophysiological recording, this may exp...
Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein [0.03%]
用于活细胞荧光寿命高通量筛选的α-突触核蛋白FRET生物传感器的技术改进
Anthony R Braun,Noah Nathan Kochen,Samantha L Yuen et al.
Anthony R Braun et al.
There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and oligomerization. Building upon our previous aSyn cellular fluorescence lifetime (FLT)-Förster r...