Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy [0.03%]
LRRC8A调节离子通道在海马腔氨烧伤内侧颞叶癫痫小鼠模型中的作用机制研究
Manolia R Ghouli,Carrie R Jonak,Rajan Sah et al.
Manolia R Ghouli et al.
Volume-regulated anion channels (VRACs) are a group of ubiquitously expressed outwardly-rectifying anion channels that sense increases in cell volume and act to return cells to baseline volume through an efflux of anions and organic osmolyt...
Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice [0.03%]
小胶质细胞和神经元的Panx1支持小鼠长期参照记忆
Price Obot,Galadu Subah,Antonia Schonwald et al.
Price Obot et al.
Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate). In the nervous system, activation of Panx1 channels has been exte...
Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and l in28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure [0.03%]
N-甲基-D天冬氨酸(NMDA)暴露诱导星形胶质细胞间信号依赖性多能基因Nestin和l in28的表达
Ana Karen Carapia,Erick J Martinez-Colin,Deisy Segura-Villalobos et al.
Ana Karen Carapia et al.
Retinal Müller cells secrete extracellular vesicles that can be captured by other Müller cells. In response to a signal that may be deleterious for the retina, Müller glia-derived extracellular vesicles spread instructions to induce gene...
Na Ji,Mengzhu Lei,Yating Chen et al.
Na Ji et al.
Depression increasingly affects a wide range and a large number of people worldwide, both physically and psychologically, which makes it a social problem requiring prompt attention and management. Accumulating clinical and animal studies ha...
Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion [0.03%]
十八肽神经降压素（ODN）的性别二态性调节室旁核糖皮质激素神经元的功能及应急激素的释放
Karen P Briski,Prabhat R Napit,Abdulrahman Alhamyani et al.
Karen P Briski et al.
Central endozepinergic signaling is implicated in glucose homeostasis. Ventromedial hypothalamic nucleus (VMN) metabolic monitoring governs glucose counter-regulation. VMN glucose-stimulatory nitric oxide (NO) and glucose-inhibitory γ-amin...
María Julia Pérez,Tomas Roberto Carden,Paula Ayelen Dos Santos Claro et al.
María Julia Pérez et al.
Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse neuroblastoma cell li...
Activation of the PACAP/PAC1 Signaling Pathway Accelerates the Repair of Impaired Spatial Memory Caused by an Ultradian Light Cycle [0.03%]
PACAP/PAC1信号通路的激活加速了 ultradian光照周期引起的受损空间记忆的修复
Dejiao Xu,Ying Zhang,Jun Feng et al.
Dejiao Xu et al.
The mechanism of light-induced spatial memory deficits, as well as whether rhythmic expression of the pituitary adenylyl cyclase-activating polypeptides (PACAP)-PAC1 pathway influenced by light is related to this process, remains unclear. H...
Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline [0.03%]
多西环素对帕金森病模型大鼠左旋多巴诱导的异动症背侧纹状体内NG2细胞影响的作用及机制研究
G C Nascimento,M Bortolanza,A Bribian et al.
G C Nascimento et al.
NG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia ...
Qiang Yu,Teng Guan,Ying Guo et al.
Qiang Yu et al.
Myelination contributes not only to the rapid nerve conduction but also to axonal insulation and protection. In the central nervous system (CNS), the initial myelination features a multistep process where oligodendrocyte precursor cells und...
Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia [0.03%]
酪蛋白激酶2介导HIV和阿片类药物诱导的底 ganglia中TAR-DNA结合蛋白43的病理性磷酸化
Michael Ohene-Nyako,Sara R Nass,Hope T Richard et al.
Michael Ohene-Nyako et al.
HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity a...