Abnormal Regulation of Mitochondrial Sphingolipids during Aging and Alzheimer's Disease [0.03%]
衰老和阿尔茨海默病中线粒体鞘脂的异常调节
Simone M Crivelli,Zainuddin Quadri,Ahmed Elsherbini et al.
Simone M Crivelli et al.
During pathogenesis of Alzheimer's disease (AD), mitochondria suffer alterations that lead to low energy production and reactive oxygen species formation. However, the mechanism of impaired mitochondria homeostasis in AD is not fully unders...
Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development and Myelination [0.03%]
星形胶质细胞Ephrin-B1调控少突胶质细胞发育和髓鞘形成
Samantha N Sutley-Koury,Alyssa Anderson,Christopher Taitano-Johnson et al.
Samantha N Sutley-Koury et al.
Astrocytes have been implicated in oligodendrocyte development and myelination, however, the mechanisms by which astrocytes regulate oligodendrocytes remain unclear. Our findings suggest a new mechanism that regulates astrocyte-mediated oli...
Dorsomedial Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neuron Steroidogenic Factor-1 Gene Targets in Female Rat [0.03%]
雌性大鼠腹内侧视上核生长激素释放激素神经元类固醇生成因子-1基因的靶位点
Subash Sapkota,Sagor C Roy,Karen P Briski
Subash Sapkota
The prospect that the ventromedial hypothalamic nucleus (VMN) transcription factor steroidogenic factor-1/NR5A1 (SF-1) may exert sex-dimorphic control of glucose counterregulation is unresolved. Recent studies in male rats show that SF-1 re...
Quantitative Analysis of Early White Matter Damage in Cuprizone Mouse Model of Demyelination Using 7.0 T MRI Multiparametric Approach [0.03%]
利用7.0T磁共振多参数方法定量分析氯化铜小鼠脱髓鞘模型早期白质损伤
Emma Friesen,Maxina Sheft,Kamya Hari et al.
Emma Friesen et al.
Magnetic Resonance Imaging (MRI) is commonly used to follow the progression of neurodegenerative conditions, including multiple sclerosis (MS). MRI is limited by a lack of correlation between imaging results and clinical presentations, refe...
Implications of Iron in Ferroptosis, Necroptosis, and Pyroptosis as Potential Players in TBI Morbidity and Mortality [0.03%]
铁死亡、坏死性凋亡和细胞焦亡在创伤性脑损伤致病致死中的潜在作用及其意义
Makenzie Nolt,James Connor
Makenzie Nolt
Iron is a critical transition metal required to sustain a healthy central nervous system. Iron is involved in metabolic reactions, enzymatic activity, myelinogenesis, and oxygen transport. However, in several pathological conditions such as...
Douglas L Feinstein
Douglas L Feinstein
Cellular Mechanisms of Cognitive Enhancement: The In Vivo Modulation of the Firing Activity and the Responsiveness of Rat Hippocampal Neurons by Memantine and Alpha7 Nicotinic Acetylcholine Receptor Ligands [0.03%]
认知增强的细胞机制：Memantine和α7烟碱乙酰胆碱受体配体对大鼠海马神经元放电活动及反应性行为的体内调节作用
Lili Veronika Nagy,Zsolt Kristóf Bali,István Ledneczki et al.
Lili Veronika Nagy et al.
Promising new pharmacological strategies for the enhancement of cognition target either nicotinic acetylcholine receptors (nAChR) or N-methyl-D-aspartate receptors (NMDAR). There is also an increasing interest in low-dose combination therap...
Reduced Expression of Oligodendrocyte Linage-Enriched Transcripts During the Endoplasmic Reticulum Stress/Integrated Stress Response [0.03%]
内质网应激/综合应激反应下调寡神经胶细胞谱系富集转录本的表达
Yonglin Gao,Lukasz P Slomnicki,Ewa Kilanczyk et al.
Yonglin Gao et al.
Endoplasmic reticulum (ER) stress in oligodendrocyte (OL) linage cells contributes to several CNS pathologies including traumatic spinal cord injury (SCI) and multiple sclerosis. Therefore, primary rat OL precursor cell (OPC) transcriptomes...
Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior Deficits [0.03%]
早发性癫痫导致社交行为缺损的新型通道调节因子Panx1
Price Obot,Antonio Cibelli,Jian Pan et al.
Price Obot et al.
There is a high co-morbidity between childhood epilepsy and autism spectrum disorder (ASD), with age of seizure onset being a critical determinant of behavioral outcomes. The interplay between these comorbidities has been investigated in an...
Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat [0.03%]
雄性大鼠DMVMN促生长激素释放素神经元类固醇生成因子-1，神经递质标记物及雌激素受体基因表达的研究
Subash Sapkota,Sagor C Roy,Rami Shrestha et al.
Subash Sapkota et al.
Ventromedial hypothalamic nucleus (VMN) growth hormone-releasing hormone (Ghrh) neurotransmission shapes counterregulatory hormone secretion. Dorsomedial VMN Ghrh neurons express the metabolic-sensitive transcription factor steroidogenic fa...