A Brain Endothelial Cell Caveolin-1/CXCL10 Axis Promotes T Cell Transcellular Migration Across the Blood-Brain Barrier [0.03%]
脑血管内皮细胞的洞蛋白-1/ CXCL10 轴促进T细胞穿越血脑屏障发生迁移
Troy N Trevino,Ali A Almousawi,Remy Martins-Goncalves et al.
Troy N Trevino et al.
The mechanisms that govern whether T cells cross blood-brain barrier (BBB) endothelium by transcellular versus paracellular routes are unclear. Caveolin-1 is a membrane scaffolding and signaling protein associated with transcellular transmi...
A Statistically-Robust Model of the Axomyelin Unit under Normal Physiologic Conditions with Application to Disease States [0.03%]
正常生理条件下轴突-髓鞘单位的统计学稳健模型及其在病理状态下的应用
Alexander Gow,Jeffrey L Dupree,Douglas L Feinstein et al.
Alexander Gow et al.
Despite tremendous progress in characterizing the myriad cellular structures in the nervous system, a full appreciation of the interdependent and intricate interactions between these structures is as yet unfulfilled. Indeed, few more so tha...
Joyce Benjamins,Pamela Knapp,Anne Boullerne
Joyce Benjamins
Understanding the Myelin g Ratio from First Principles, Its Derivation, Uses and Artifacts [0.03%]
从第一性原理理解髓鞘g比值及其推导、用途和伪像
Alexander Gow
Alexander Gow
In light of the increasing importance for measuring myelin g ratios - the ratio of axon-to-fiber (axon + myelin) diameters in myelin internodes - to understand normal physiology, disease states, repair mechanisms and myelin plasticity, ther...
Neurons Are Not All the Same: Diversity in Neuronal Populations and Their Intrinsic Responses to Spinal Cord Injury [0.03%]
神经元并不相同：神经元群体的多样性及其对脊髓损伤的内在反应
Justin R Siebert,Kiersten Kennedy,Donna J Osterhout
Justin R Siebert
Functional recovery following spinal cord injury will require the regeneration and repair of damaged neuronal pathways. It is well known that the tissue response to injury involves inflammation and the formation of a glial scar at the lesio...
New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia [0.03%]
新发现的Atg9磷酸化位点调节胶质细胞自噬转运
Linfang Wang,Shuanglong Yi,Shiping Zhang et al.
Linfang Wang et al.
We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present evidence here that lack of glial d...
Sex Affects Cognitive Outcomes in HIV-1 Tat Transgenic Mice: Role of CCR5 [0.03%]
HIV-1感染小鼠TA突变型转基因对认知功能的影响及CCR5的作用机制研究
Chloe A Simons,Sarah Kim,Yun K Hahn et al.
Chloe A Simons et al.
People living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HAND), even though combination antiretroviral therapy (cART) suppresses HIV replication. HIV-1 transactivator of transcription (HIV-1 Tat) contributes to the ...
Joyce Benjamins,Pamela Knapp,Anne Boullerne
Joyce Benjamins
Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells [0.03%]
氨基酸和葡萄糖发酵可维持小鼠和人类恶性胶质瘤细胞的ATP含量
Derek C Lee,Linh Ta,Purna Mukherjee et al.
Derek C Lee et al.
Energy is necessary for tumor cell viability and growth. Aerobic glucose-driven lactic acid fermentation is a common metabolic phenotype seen in most cancers including malignant gliomas. This metabolic phenotype is linked to abnormalities i...
Felecia M Marottoli,Deebika Balu,Rohan Chaudhary et al.
Felecia M Marottoli et al.
Brain endothelial cells are critical for homeostasis of the central nervous system. Novel adeno-associated viruses (AAV) with brain endothelial cell tropism have been developed and are beginning to be employed in mechanistic and therapeutic...