Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway [0.03%]
由代谢型谷氨酸受体和磷脂酶C通路介导的皮层少突胶质细胞BDNF的释放受调节
Issa P Bagayogo,Cheryl F Dreyfus
Issa P Bagayogo
A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons. What is less clea...
Comparative Study
ASN neuro. 2009 Apr 14;1(1):e00001. DOI:10.1042/AN20090006 2009
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions [0.03%]
富亮氨酸重复激酶2基因突变与帕金森病：三个问题
Elisa Greggio,Mark R Cookson
Elisa Greggio
Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson's disease. The protein is a large GTP-regulated serine/thr...
Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins [0.03%]
高尔基蛋白通过调节少突胶质前体细胞中的 stored 和电压控制Ca2+通道来调控少突胶质前体细胞的增殖和死亡
Pablo M Paez,Daniel J Fulton,Vilma Spreuer et al.
Pablo M Paez et al.
OPCs (oligodendrocyte precursor cells) express golli proteins which, through regulation of Ca2+ influx, appear to be important in OPC process extension/retraction and migration. The aim of the present study was to examine further the role o...
Comparative Study
ASN neuro. 2009 Apr 14;1(1):e00003. DOI:10.1042/AN20090003 2009
Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury [0.03%]
缺少X染色体凋亡抑制蛋白蛋白导致新生儿脑损伤后凋亡和组织损失增加
Tim West,Madeliene Stump,Gregory Lodygensky et al.
Tim West et al.
Neurological deficits caused by H-I (hypoxia-ischaemia) to the perinatal brain are often severely debilitating and lead to motor impairment, intellectual disability and seizures. Perinatal brain injury is distinct from adult brain injury in...
Comparative Study
ASN neuro. 2009 Apr 14;1(1):e00004. DOI:10.1042/AN20090005 2009
Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes [0.03%]
小鼠P2X7受体的点突变影响星形胶质细胞间的胞内钙波
Sylvia O Suadicani,Rodolfo Iglesias,David C Spray et al.
Sylvia O Suadicani et al.
Purinergic P2 receptors and gap junctions are two groups of proteins involved in the transmission of ICWs (intercellular calcium waves) between astrocytes. The extent to which ICWs spread among these glial cells depends on the amount of ATP...
Comparative Study
ASN neuro. 2009 Apr 14;1(1):e00005. DOI:10.1042/AN20090001 2009