Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins [0.03%]
PPARδ调控少突胶质前体细胞向成熟少突胶质细胞分化及其对骨形态发生蛋白信号通路的影响
Maria Vittoria Simonini,Paul E Polak,Anne I Boullerne et al.
Maria Vittoria Simonini et al.
In EAE (experimental autoimmune encephalomyelitis), agonists of PPARs (peroxisome proliferator-activated receptors) provide clinical benefit and reduce damage. In contrast with PPARγ, agonists of PPARδ are more effective when given at lat...
Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice [0.03%]
CCR3缺乏小鼠周围性面神经麻痹后颜面运动神经元丢失加重
Derek A Wainwright,Junping Xin,Nichole A Mesnard et al.
Derek A Wainwright et al.
We have previously demonstrated a neuroprotective mechanism of FMN (facial motoneuron) survival after facial nerve axotomy that is dependent on CD4(+) Th2 cell interaction with peripheral antigen-presenting cells, as well as CNS (central ne...
Filming the glial dreams: real-time imaging of cannabinoid receptor trafficking in astrocytes [0.03%]
用实时成像技术拍摄星形胶质细胞的胶质梦想： cannabinoid受体转运内化过程研究
Alexei Verkhratsky
Alexei Verkhratsky
How does the brain process incoming information and produce thoughts? These questions represent, to all likelihood, the most challenging matters ever faced by natural sciences, matters which may never be fully comprehended. The evolution of...
Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes [0.03%]
cultured astrocytes中Cannabinoid受体1囊泡转运的动态影像学研究
Kyle D Osborne,William Lee,Erik B Malarkey et al.
Kyle D Osborne et al.
Astrocytes possess GPCRs (G-protein-coupled receptors) for neuroactive substances and can respond via these receptors to signals originating from neurons as well as astrocytes. Like many transmembrane proteins, GPCRs exist in a dynamic equi...
Comparative Study
ASN neuro. 2009 Dec 8;1(5):e00022. DOI:10.1042/AN20090040 2009
Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release [0.03%]
凋亡诱导因子在外线粒体膜定位的机制意义及其释放情况
Seong-Woon Yu,Yingfei Wang,Didrik S Frydenlund et al.
Seong-Woon Yu et al.
Poly(ADP-ribose) polymerase-1-dependent cell death (known as parthanatos) plays a pivotal role in many clinically important events including ischaemia/reperfusion injury and glutamate excitotoxicity. A recent study by us has shown that uncl...
Altered hippocampal morphology in unmedicated patients with major depressive illness [0.03%]
未经治疗的主要抑郁障碍患者的海马形态改变
Carrie E Bearden,Paul M Thompson,Christina Avedissian et al.
Carrie E Bearden et al.
Despite converging evidence that major depressive illness is associated with both memory impairment and hippocampal pathology, findings vary widely across studies and it is not known whether these changes are regionally specific. In the pre...
Comparative Study
ASN neuro. 2009 Nov 10;1(4):e00020. DOI:10.1042/AN20090026 2009
Animal models for Alzheimer's disease and frontotemporal dementia: a perspective [0.03%]
阿尔茨海默病和额颞叶痴呆的动物模型：一种观点
Jürgen Götz,Naeman N Götz
Jürgen Götz
In dementia research, animal models have become indispensable tools. They not only model aspects of the human condition, but also simulate processes that occur in humans and hence provide insight into how disease is initiated and propagated...
Targeted ablation and reorganization of the principal preplate neurons and their neuroblasts identified by golli promoter transgene expression in the neocortex of mice [0.03%]
利用golli启动子转基因标记的小鼠新皮层主要早产板神经元及其神经前体的靶向消融与重建
Yuan-Yun Xie,Erin Jacobs,Robin Fisher
Yuan-Yun Xie
The present study delineates the cellular responses of dorsal pallium to targeted genetic ablation of the principal preplate neurons of the neocortex. Ganciclovir treatment during prenatal development (E11-E13; where E is embryonic day) of ...
The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation [0.03%]
神经源性碱性螺旋环(loop)-富勒烯 transcription 因子NeuroD6同时增加线粒体质量并在神经元分化早期调节细胞骨架组织
Kristin Kathleen Baxter,Martine Uittenbogaard,Jeongae Yoon et al.
Kristin Kathleen Baxter et al.
Mitochondria play a central role during neurogenesis by providing energy in the form of ATP for cytoskeletal remodelling, outgrowth of neuronal processes, growth cone activity and synaptic activity. However, the fundamental question of how ...
Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination [0.03%]
髓鞘少突胶质细胞糖皮质激素诱导蛋白样(myelin oligodendrocyte glycoprotein)蛋白一个异构体在少突胶质细胞中的表达异常导致少突胶质细胞成熟和髓鞘形成异常
Erin C Jacobs,Samuel D Reyes,Celia W Campagnoni et al.
Erin C Jacobs et al.
Recently, several in vitro studies have shown that the golli-myelin basic proteins regulate Ca2+ homoeostasis in OPCs (oligodendrocyte precursor cells) and immature OLs (oligodendrocytes), and that a number of the functions of these cells a...