Growth defects in the dorsal pallium after genetically targeted ablation of principal preplate neurons and neuroblasts: a morphometric analysis [0.03%]
背侧苍白球中主要预板神经元和神经母细胞遗传靶向消融后生长缺陷的形态计量学分析
Robin Fisher,Yuan-Yun Xie
Robin Fisher
The present study delineates the large-scale, organic responses of growth in the dorsal pallium to targeted genetic ablations of the principal PP (preplate) neurons of the neocortex. Ganciclovir treatment during prenatal development [from E...
Comparative Study
ASN neuro. 2010 Oct 4;2(5):e00046. DOI:10.1042/AN20100022 2010
Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1α antigens in the brain [0.03%]
阿尔茨海默病转基因小鼠模型中的神经节苷脂代谢：脑内Chol-1α抗原的表达
Toshio Ariga,Makoto Yanagisawa,Chandramohan Wakade et al.
Toshio Ariga et al.
The accumulation of Aβ (amyloid β-protein) is one of the major pathological hallmarks in AD (Alzheimer's disease). Gangliosides, sialic acid-containing glycosphingolipids enriched in the nervous system and frequently used as biomarkers as...
Comparative Study
ASN neuro. 2010 Oct 4;2(4):e00044. DOI:10.1042/AN20100021 2010
Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain [0.03%]
Plp1基因表达上调引起大脑小胶质细胞活化及炎症反应
Carrie L Tatar,Sunita Appikatla,Denise A Bessert et al.
Carrie L Tatar et al.
PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] g...
Comparative Study
ASN neuro. 2010 Sep 27;2(4):e00043. DOI:10.1042/AN20100016 2010
Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy [0.03%]
耐糖：糖尿病性神经病变的替代治疗方法
Nigel A Calcutt
Nigel A Calcutt
It is becoming apparent that a number of pathogenic mechanisms contribute to diabetic neuropathy, so that therapeutic interventions that target one particular mechanism may have limited success. A recently published preclinical study has ad...
Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice [0.03%]
淀粉样蛋白-β处理的培养星形胶质细胞中缝隙连接通讯下降，但阿尔茨海默病转基因小鼠中未见此现象
Nancy F Cruz,Kelly K Ball,Gerald A Dienel
Nancy F Cruz
Alzheimer's disease is characterized by accumulation of amyloid deposits in brain, progressive cognitive deficits and reduced glucose utilization. Many consequences of the disease are attributed to neuronal dysfunction, but roles of astrocy...
Comparative Study
ASN neuro. 2010 Aug 17;2(4):e00041. DOI:10.1042/AN20100017 2010
Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice [0.03%]
抑制热休克蛋白90可逆转糖尿病小鼠的痛觉减退现象
Michael J Urban,Chengyuan Li,Cuijuan Yu et al.
Michael J Urban et al.
Increasing the expression of Hsp70 (heat-shock protein 70) can inhibit sensory neuron degeneration after axotomy. Since the onset of DPN (diabetic peripheral neuropathy) is associated with the gradual decline of sensory neuron function, we ...
Comparative Study
ASN neuro. 2010 Aug 11;2(4):e00040. DOI:10.1042/AN20100015 2010
Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells [0.03%]
神经干细胞和胚胎干细胞衍生的神经细胞表达glypican-1、磷蛋白-酪氨酸磷酸酶-ζ/β及其配体ntenascin-C
Mary Abaskharoun,Marie Bellemare,Elizabeth Lau et al.
Mary Abaskharoun et al.
The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-zeta/beta and the extracellular matrix protein tenascin-C were all found to be expressed by neural ste...
Comparative Study
ASN neuro. 2010 Jul 30;2(3):e00039. DOI:10.1042/AN20100001 2010
Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse [0.03%]
卡路里限制在恶性脑瘤中的抗侵袭性治疗作用：小鼠模型研究
Laura M Shelton,Leanne C Huysentruyt,Purna Mukherjee et al.
Laura M Shelton et al.
GBM (glioblastoma multiforme) is the most aggressive and invasive form of primary human brain cancer. We recently developed a novel brain cancer model in the inbred VM mouse strain that shares several characteristics with human GBM. Using b...
Comparative Study
ASN neuro. 2010 Jul 23;2(3):e00038. DOI:10.1042/AN20100002 2010
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease [0.03%]
淀粉样蛋白转基因小鼠中TREM2和耐受相关转录本Tmem176b的双重诱导：针对阿尔茨海默病疫苗治疗的意义
Benoit Melchior,Angie E Garcia,Bor-Kai Hsiung et al.
Benoit Melchior et al.
Vaccine-based autoimmune (anti-amyloid) treatments are currently being examined for their therapeutic potential in Alzheimer's disease. In the present study we examined, in a transgenic model of amyloid pathology, the expression of two mole...
Comparative Study
ASN neuro. 2010 Jul 12;2(3):e00037. DOI:10.1042/AN20100010 2010
Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease [0.03%]
亨廷顿舞蹈病基因型小鼠模型纹状体突触传递的改变是一致的
Damian M Cummings,Carlos Cepeda,Michael S Levine
Damian M Cummings
Since the identification of the gene responsible for HD (Huntington's disease), many genetic mouse models have been generated. Each employs a unique approach for delivery of the mutated gene and has a different CAG repeat length and backgro...
Comparative Study
ASN neuro. 2010 Jun 18;2(3):e00036. DOI:10.1042/AN20100007 2010