Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis [0.03%]
瞄准VIP和PACAP受体信号传导：多发性硬化的新治疗策略
Yossan-Var Tan,James A Waschek
Yossan-Var Tan
MS (multiple sclerosis) is a chronic autoimmune and neurodegenerative pathology of the CNS (central nervous system) affecting approx. 2.5 million people worldwide. Current and emerging DMDs (disease-modifying drugs) predominantly target the...
Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? [0.03%]
假说：多形性胶质母细胞瘤中存在新生物巨噬细胞/小胶质细胞？
Leanne C Huysentruyt,Zeynep Akgoc,Thomas N Seyfried
Leanne C Huysentruyt
Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-assoc...
Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model [0.03%]
胶质母细胞瘤在体小鼠模型的现状：以CNS-1肿瘤模型为重点
Valerie L Jacobs,Pablo A Valdes,William F Hickey et al.
Valerie L Jacobs et al.
GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent mo...
Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties [0.03%]
预处理可诱导新生小胶质细胞提前分化以增强其神经保护特性
Ellora Sen,Anirban Basu,Lisa B Willing et al.
Ellora Sen et al.
Hypoxic preconditioning reprogrammes the brain's response to subsequent H/I (hypoxia-ischaemia) injury by enhancing neuroprotective mechanisms. Given that astrocytes normally support neuronal survival and function, the purpose of the presen...
Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation [0.03%]
经典Wnt信号转导需要BMP通路抑制少突胶质细胞的成熟
Keith Feigenson,Mary Reid,Jill See et al.
Keith Feigenson et al.
OLs (oligodendrocytes) are the myelinating cells of the CNS (central nervous system), wrapping axons in conductive sheathes to ensure effective transmission of neural signals. The regulation of OL development, from precursor to mature myeli...
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function [0.03%]
突变型亨廷顿蛋白在体内诱导黑质细胞自主年龄依赖性兴奋毒性敏感性和线粒体功能变化
Soong Ho Kim,Carlos A Thomas,Véronique M André et al.
Soong Ho Kim et al.
HD (Huntington's disease) is characterized by dysfunction and death of striatal MSNs (medium-sized spiny neurons). Excitotoxicity, transcriptional dysregulation and mitochondrial abnormalities are among the mechanisms that are proposed to p...
Darya Pino,Youngshik Choe,Samuel J Pleasure
Darya Pino
Neurons born in the postnatal SVZ (subventricular zone) must migrate a great distance before becoming mature interneurons of the OB (olfactory bulb). During migration immature OB neurons maintain an immature morphology until they reach thei...
Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade [0.03%]
十年来的大脑dysbindin复合体及其功能的探究：从零到太多
Cristina A Ghiani,Esteban C Dell&#x;Angelica
Cristina A Ghiani
Dysbindin (also known as dysbindin-1 or dystrobrevin-binding protein 1) was identified 10 years ago as a ubiquitously expressed protein of unknown function. In the following years, the protein and its encoding gene, DTNBP1, have become the ...
Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum [0.03%]
BALB/C和C57BL/6小鼠谷氨酸脱氢酶1(GLUD1)差异表达及Glud1基因过表达对纹状体谷氨酸释放的影响
Kevin N Hascup,Xiaodong Bao,Erin R Hascup et al.
Kevin N Hascup et al.
We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal injury and cell ...
T-cell production of matrix metalloproteinases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain [0.03%]
慢性脑部弓形虫感染期间T细胞产生基质金属蛋白酶和TIMP-1对寄生虫清除的抑制作用
Robin T Clark,J Philip Nance,Shahani Noor et al.
Robin T Clark et al.
Chronic infection with the intracellular protozoan parasite Toxoplasma gondii leads to tissue remodelling in the brain and a continuous requirement for peripheral leucocyte migration within the CNS (central nervous system). In the present s...